EP 0787150 A1 19970806 - SYNTHETIC IgE MEMBRANE ANCHOR PEPTIDE IMMUNOGENS FOR THE TREATMENT OF ALLERGY
Title (en)
SYNTHETIC IgE MEMBRANE ANCHOR PEPTIDE IMMUNOGENS FOR THE TREATMENT OF ALLERGY
Title (de)
SYNTHETISCHE MEMBRANANKER-PEPTIDIMMUNOGENE GEGEN IGE FÜR DIE BEHANDLUNG DER ALLERGIE
Title (fr)
IMMUNOGENES PEPTIDIQUES SYNTHETIQUES DU DOMAINE D'ANCRAGE DE LA MEMBRANE DE L'IGE
Publication
Application
Priority
- US 9513841 W 19951025
- US 32851994 A 19941025
Abstract (en)
[origin: WO9612740A1] The present invention relates to a method for eliciting the production in healthy mammals, including humans, of high titer antibodies specific for sites on the extracellular segment of the anchor domain of the membrane-bound epsilon heavy chain of B cell-expressed humain IgE by the use of a composition comprising a synthetic peptide immunogen containing extracellular membrane anchor sites, to reduce IgE-secreting B leukocytes and allergen-induced IgE production. It also relates to the use of optimally designed, carrier protein free, IgE epsilon -chain related immunogens as key components in a synthetic vaccine to provide an immunotherapy for the treatment of allergy. The subject peptides contain immune stimulator sequences, including a tandemly linked helper T cell epitope, to aid in stimulating the immune response towards the mIgE membrane anchor domain.
IPC 1-7
IPC 8 full level
A61K 39/00 (2006.01); C07K 14/02 (2006.01); C07K 14/12 (2006.01); C07K 16/00 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 39/0008 (2013.01); C07K 14/005 (2013.01); C07K 16/00 (2013.01); A61K 38/00 (2013.01); A61K 2039/6018 (2013.01); A61K 2039/6031 (2013.01); A61K 2039/64 (2013.01); C12N 2730/10122 (2013.01); C12N 2760/18422 (2013.01)
Citation (search report)
See references of WO 9612740A1
Designated contracting state (EPC)
BE CH DE FR GB LI NL
DOCDB simple family (publication)
WO 9612740 A1 19960502; AU 4012095 A 19960515; CA 2203165 A1 19960502; CN 1167491 A 19971210; EP 0787150 A1 19970806
DOCDB simple family (application)
US 9513841 W 19951025; AU 4012095 A 19951025; CA 2203165 A 19951025; CN 95196496 A 19951025; EP 95938912 A 19951025