EP 0792294 A1 19970903 - HUMAN ANTIBODIES TO T-CELL RECEPTOR PEPTIDES AND METHODS FOR THEIR PREPARATION
Title (en)
HUMAN ANTIBODIES TO T-CELL RECEPTOR PEPTIDES AND METHODS FOR THEIR PREPARATION
Title (de)
HUMANE ANTIKÖRPER GEGEN T-ZELLREZEPTORPEPTIDEN UND VERFAHREN ZU DERER HERSTELLUNG
Title (fr)
ANTICORPS HUMAINS POUR LES PEPTIDES RECEPTEURS DE LYMPHOCYTES T ET LEUR METHODE DE PREPARATION
Publication
Application
Priority
- US 9514869 W 19951115
- US 34115794 A 19941116
Abstract (en)
[origin: WO9615153A1] Human antibody preparations enriched for antibodies that bind to human T-cell receptor peptide or conformational determinants are disclosed. Also disclosed are methods for making such antibody preparations from human plasma Cohn fractions by immunoaffinity purification using either recombinant Tcr protein or Tcr variable region peptides. Purification of Tcr antibodies from human or animal antibody mixtures is accomplished by immunoaffinity procedures using recombinant human T-cell receptor proteins. The affinity purified antibodies can bind to intact membrane-bound Tcr using fluorescence activated cell sorting (FACS) and can inhibit T-cell proliferation following stimulation by mitogen. Affinity purified human polyclonal antibodies can inhibit lytic activity of natural killer cells on a monoclonal T-cell line. The antibody preparations can be used for diagnosis, monitoring and therapy of various autoimmune-related syndromes.
IPC 1-7
IPC 8 full level
G01N 33/53 (2006.01); A61K 39/395 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); C07K 1/22 (2006.01); C07K 16/06 (2006.01); C07K 16/28 (2006.01); G01N 33/531 (2006.01); G01N 33/564 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 29/00 (2017.12); A61P 37/00 (2017.12); C07K 16/065 (2013.01); C07K 16/2809 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9615153A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9615153 A1 19960523; AU 4161196 A 19960606; AU 705010 B2 19990513; CA 2205138 A1 19960523; EP 0792294 A1 19970903; JP H10509948 A 19980929
DOCDB simple family (application)
US 9514869 W 19951115; AU 4161196 A 19951115; CA 2205138 A 19951115; EP 95939984 A 19951115; JP 51631795 A 19951115