EP 0794944 A1 19970917 - PERHYDROISOINDOLE DERIVATIVES AS ANTAGONISTS OF SUBSTANCE P
Title (en)
PERHYDROISOINDOLE DERIVATIVES AS ANTAGONISTS OF SUBSTANCE P
Title (de)
PERHYDROISOINDOLDERIVATE ALS SUBSTANZ P ANTAGONISTEN
Title (fr)
DERIVES DE PERHYDROISOINDOLE COMME ANTAGONISTES DE LA SUBSTANCE P
Publication
Application
Priority
- FR 9501577 W 19951129
- FR 9414345 A 19941130
Abstract (en)
[origin: WO9616939A1] New perhydroinsoindole having the general formula (I) wherein R1 is optionally substituted phenyl or is cyclohexadienyl, naphtyl, indenyl or mono or polycyclic heterocyclyl, saturated or unsaturated 5 to 9C and optionally substituted, R2 is H or halogen, OH, alkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, alkyloxycarbonyl, dialkylaminoalcyloxycarbonyl, benzyloxycarbonyl, amino or acylamino, R3 is phenyl optionally substituted in position -2 by a radical alkyl or alkyloxy 1 or 2C or by OH or F, or disubstituted by CF3, and R4 is an alkyl radical containing 1 or 2C substituted by halogen or CN, N3 or -NHCN, and the radicals R which are similar or different represent H, alkyl or phenyl, in their isomer forms having the structure (Ia) or mixtures thereof, optionally their salts when they exist and preparation thereof. The new derivatives of the invention are particularly useful as antagonists of substance P.
IPC 1-7
IPC 8 full level
A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/4035 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/4433 (2006.01); A61P 1/00 (2006.01); A61P 9/00 (2006.01); A61P 11/00 (2006.01); A61P 25/00 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07D 209/44 (2006.01); C07D 401/06 (2006.01); C07D 409/06 (2006.01)
CPC (source: EP US)
A61P 1/00 (2018.01 - EP); A61P 9/00 (2018.01 - EP); A61P 11/00 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 27/02 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 209/44 (2013.01 - EP US); C07D 401/06 (2013.01 - EP US); C07D 409/06 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9616939 A1 19960606; AU 4265496 A 19960619; EP 0794944 A1 19970917; FR 2727411 A1 19960531; FR 2727411 B1 19970103; IL 116154 A0 19960131; JP H10509970 A 19980929; US 5739351 A 19980414; ZA 9510146 B 19960606
DOCDB simple family (application)
FR 9501577 W 19951129; AU 4265496 A 19951129; EP 95941161 A 19951129; FR 9414345 A 19941130; IL 11615495 A 19951127; JP 51834096 A 19951129; US 84917797 A 19970530; ZA 9510146 A 19951129