EP 0795011 A1 19970917 - METHOD AND COMPOSITIONS FOR REDUCING CHOLESTEROL ABSORPTION
Title (en)
METHOD AND COMPOSITIONS FOR REDUCING CHOLESTEROL ABSORPTION
Title (de)
VERFAHREN UND ZUSAMMENSETZUNGEN ZUR SENKUNG DER CHOLESTERINABSORBTION
Title (fr)
TECHNIQUE ET COMPOSITIONS PERMETTANT DE REDUIRE L'ABSORPTION DE CHOLESTEROL
Publication
Application
Priority
- US 9515647 W 19951201
- US 34771894 A 19941201
- US 47916095 A 19950607
- US 48226295 A 19950607
Abstract (en)
[origin: WO9617054A1] Compositions derived from all or a portion of the carboxy terminal region of human bile salt-activated lipase (BAL) are described, which, when orally ingested, compete with native BAL in binding to the intestinal surface, thus reducing the physiological role of BAL in mediating the transfer of cholesterol into the intestinal cells, and, as a result, reducing the amount of cholesterol absorbed from the intestine into the blood stream. Useful derivatives of the carboxy terminal region of BAL are derived from all or portion of the region containing amino acid residues 539 to 722, and have a mucin-like structure containing at least three of the repeating proline-rich units of eleven amino acid residues each.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); A61K 31/70 (2006.01); A61K 38/46 (2006.01); A61K 45/00 (2006.01); A61K 47/48 (2006.01); A61K 51/04 (2006.01); A61P 3/06 (2006.01); C12N 9/20 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 51/0493 (2013.01); A61P 3/00 (2017.12); A61P 3/06 (2017.12); C12N 9/20 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9617054A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9617054 A1 19960606; AU 4506496 A 19960619; AU 707558 B2 19990715; CA 2206526 A1 19960606; EP 0795011 A1 19970917; JP 3007161 B2 20000207; JP H10510166 A 19981006
DOCDB simple family (application)
US 9515647 W 19951201; AU 4506496 A 19951201; CA 2206526 A 19951201; EP 95943643 A 19951201; JP 51909596 A 19951201