EP 0796101 A1 19970924 - COMPOSITIONS AND METHODS FOR INHIBITING FUNGAL CELL WALL FORMATION
Title (en)
COMPOSITIONS AND METHODS FOR INHIBITING FUNGAL CELL WALL FORMATION
Title (de)
MITTEL UND VERFAHREN ZUR HEMMUNG DER ZELLWANDBILDUNG VON PILZEN
Title (fr)
COMPOSITIONS ET PROCEDES POUR INHIBER LA FORMATION DE CERTAINES PAROIS CELLULAIRES FONGIQUES
Publication
Application
Priority
- US 9600752 W 19960102
- US 36859195 A 19950104
Abstract (en)
[origin: WO9620717A1] Disclosed herein are antifungal compositions having an oligosaccharide that includes an N-acetylhexosamine residue linked beta (1}4) to a hexose and a biologically acceptable carrier. The isolation of the fungal enzyme chitin glucan beta (1}4) transferase (CG beta (1}4)T) is disclosed along with methods for using this enzyme in an assay for antifungal agents. CG beta (1}4)T catalyses the formation of a beta (1}4) linkage between the terminal reducing N-acetylglucosamine residue of chitin and the non-reducing glucose residue of beta (1}3) linked glucans. Inhibitors of the enzyme, antifungals including such inhibitors, methods for the prevention and the treatment of fungal infections in animals and plants, and screening methods for identifying antifungals are also disclosed.
IPC 1-7
A61K 31/70; C12N 9/10; C12N 9/24; C07K 14/37; C07K 14/38; C07K 14/395
IPC 8 full level
C12N 9/24 (2006.01); A61K 31/70 (2006.01); A61K 31/7008 (2006.01); A61P 31/04 (2006.01); A61P 31/10 (2006.01); C07H 5/04 (2006.01); C07H 7/02 (2006.01); C07H 7/04 (2006.01); C07K 14/37 (2006.01); C12N 9/10 (2006.01); C12R 1/645 (2006.01); C12R 1/725 (2006.01)
CPC (source: EP)
A61K 31/70 (2013.01); A61K 31/7008 (2013.01); A61K 31/7016 (2013.01); A61K 31/702 (2013.01); A61K 36/06 (2013.01); A61K 36/062 (2013.01); A61K 36/064 (2013.01); A61K 36/07 (2013.01); A61P 31/04 (2017.12); A61P 31/10 (2017.12); C12N 9/1051 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9620717 A1 19960711; AU 4964496 A 19960724; AU 702725 B2 19990304; CA 2209663 A1 19960711; EP 0796101 A1 19970924; EP 0796101 A4 20001011; JP H10512247 A 19981124
DOCDB simple family (application)
US 9600752 W 19960102; AU 4964496 A 19960102; CA 2209663 A 19960102; EP 96906177 A 19960102; JP 52129396 A 19960102