Global Patent Index - EP 0796277 A4

EP 0796277 A4 20010124 - REAGENTS AND PROCESSES FOR TARGETING MUTANT EPIDERMAL GROWTH FACTOR RECEPTORS

Title (en)

REAGENTS AND PROCESSES FOR TARGETING MUTANT EPIDERMAL GROWTH FACTOR RECEPTORS

Title (de)

REAGENTIEN UND VERFAHREN ZUR ÜBEREXPRESSION VON MÜTIERTEN EPIDERMALEN WACHSTUMSFAKTORREZEPTOREN

Title (fr)

REACTIFS ET PROCEDE DE CIBLAGE DES RECEPTEURS MUTANTS DU FACTEUR DE CROISSANCE DE L'EPIDERME

Publication

EP 0796277 A4 20010124 (EN)

Application

EP 95943342 A 19951128

Priority

  • US 9515401 W 19951128
  • US 34752094 A 19941128

Abstract (en)

[origin: WO9616988A1] Cell lines are provided for the overexpression of Type III mutant EGF receptor. Method of producing these cell lines are also provided. In addition, antibodies raised against peptides expressed by these cell lines are provided. Vaccines comprising peptides from a fusion junction present in a mutant human EGF receptor and methods of using these vaccines in the inhibition of tumor formation and enhancement of tumor regression are also provided. Further, antisense oligonucleotides targeted to a mutant EGF receptor which decreases expression of a mutant EGF receptor are disclosed.

IPC 1-7

C12N 15/12; A61K 38/17; C07K 14/70; C07K 14/71; C07K 16/28; C12N 5/10

IPC 8 full level

C12N 15/09 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); C07K 14/71 (2006.01); C07K 16/28 (2006.01); C12N 5/00 (2006.01); C12N 5/10 (2006.01); C12N 15/00 (2006.01); C12N 15/02 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); A61K 39/00 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP)

A61P 35/00 (2018.01); A61P 37/04 (2018.01); C07K 14/71 (2013.01); A61K 39/00 (2013.01)

Citation (search report)

  • [X] WO 9103489 A1 19910321 - UNIV JOHNS HOPKINS [US], et al
  • [XD] HUMPHREY P A ET AL: "ANTI-SYNTHETIC PEPTIDE ANTIBODY REACTING AT THE FUSION JUNCTION OF DELETION-MUTANT EPIDERMAL GROWTH FACTOR RECEPTORS IN HUMAN GLIOBLASTOMA", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 87, no. 11, 1 June 1990 (1990-06-01), pages 4207 - 4211, XP000133024, ISSN: 0027-8424
  • [X] GARCIA DE PALAZZO I. ET AL.: "Expression of mutated Epidermal Growth Factor Receptor by non-small cell lung carcinomas", CANCER RES., vol. 53, 15 July 1993 (1993-07-15), pages 3217 - 3220, XP002153548
  • [A] VELU T.J. ET AL.: "Retroviruses expressing different levels of the normal epidermal growth factor receptor: biological properties and new bioassay.", J. CELL. BIOCHEM., vol. 39, 1989, pages 153 - 166, XP000946629
  • [A] RIEDEL H. ET AL.: "Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts", PROC.NATL. ACAD. SCI. USA, vol. 85, March 1988 (1988-03-01), pages 1477 - 1481, XP002148731
  • [PX] WIKSTRAND C J ET AL: "MONOCLONAL ANTIBODIES AGAINST EGFRVIII ARE TUMOR SPECIFIC AND REACT WITH BREAST AND LUNG CARCINOMAS AND MALIGNANT GLIOMAS", CANCER RESEARCH,US,AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, vol. 55, 15 July 1995 (1995-07-15), pages 3140 - 3148, XP002074673, ISSN: 0008-5472
  • See also references of WO 9616988A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9616988 A1 19960606; AT 262586 T 20040415; CA 2206343 A1 19960606; CA 2206343 C 20090407; DE 69532767 D1 20040429; DE 69532767 T2 20040812; EP 0796277 A1 19970924; EP 0796277 A4 20010124; EP 0796277 B1 20040324; JP 2007297398 A 20071115; JP 4620808 B2 20110126; JP H10509878 A 19980929; US 6224868 B1 20010501

DOCDB simple family (application)

US 9515401 W 19951128; AT 95943342 T 19951128; CA 2206343 A 19951128; DE 69532767 T 19951128; EP 95943342 A 19951128; JP 2007167580 A 20070626; JP 51898296 A 19951128; US 86142397 A 19970521