Global Patent Index - EP 0796322 A4

EP 0796322 A4 2000-04-26 - PRODUCTION AND USE OF HUMAN AND PLANT METHYLTRANSFERASES

Title (en)

PRODUCTION AND USE OF HUMAN AND PLANT METHYLTRANSFERASES

Title (de)

HERSTELLUNG UND VERWENDUNG MENSCHLICHER UND PFLANZICHER METHYLTRANSFERASEN

Title (fr)

PRODUCTION ET UTILISATION DE METHYLTRANSFERASES DE L'HOMME ET DES PLANTES

Publication

EP 0796322 A4 (EN)

Application

EP 95939576 A

Priority

  • US 9513691 W
  • US 32677494 A

Abstract (en)

[origin: WO9612797A1] An isolated recombinant human L-isoaspartyl/D-aspartyl protein methyltransferase is obtained by overexpression of cDNA coding for isozyme II in an E. coli strain, and a cDNA clone of the wheat enzyme and a purified enzyme from wheat are obtained. These enzymes are useful in treatment of medical conditions and diagnosis of disease associated with an increase in L-isoaspartyl/D-aspartyl residues of polypeptides in a tissue.

IPC 1-7 (main, further and additional classification)

C12N 9/10; A61K 38/51; C12N 15/63; C12N 15/82; C12P 21/06

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 8/00 (2006.01); A61K 8/30 (2006.01); A61K 8/66 (2006.01); A61K 31/70 (2006.01); A61K 38/45 (2006.01); A61P 9/00 (2006.01); A61P 13/02 (2006.01); A61P 15/00 (2006.01); A61P 17/00 (2006.01); A61P 25/28 (2006.01); A61P 27/02 (2006.01); A61Q 5/00 (2006.01); C12N 9/10 (2006.01); C12N 15/00 (2006.01); C12Q 1/48 (2006.01); A61K 38/00 (2006.01); C12R 1/19 (2006.01); C12R 1/91 (2006.01)

CPC (invention and additional information)

C12N 9/1007 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [DA] US 5273886 A 19931228 - ASWAD DANA W [US]
  • [XD] SATO M. ET AL.,: "Primary structure of rat brain protein carboxyl methyltransferase deduced from cDNA sequence", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 161, 1989, pages 342-347, XP002121862
  • [X] MIZOBUCHI M. ET AL.,: "Tissue-specific expression of isoaspartyl protein carboxyl methyltransferase gene in rat brain and testis", J. NEUROCHEM., vol. 62, 1994, pages 322-328, XP002121863
  • [XD] INGROSSO, D. ET AL.,: "Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases.", J. BIOL. CHEM., vol. 264, 1989, pages 20131-20139, XP002121864
  • [XD] ROMANIK E.A. ET AL.,: "Genomic organization and tissue expression of the murine gene encoding the protein beta-aspartate methyltransferase", GENE, vol. 118, 1992, pages 217-222, XP002121865
  • [X] W.J. HENZEL ET AL.,: "The primary structure of a protein carboxyl methyltransferase from bovine brain that selectively methylates L-isoaspartyl sites", J. BIOL. CHEM., vol. 264, no. 27, 1989, pages 15905 - 15911, XP002121866
  • [X] MUDGETT M.B., CLARKE S.: "Characterization of plant L-isoaspartyl methyltransferases that may be involved in seed survival: Purification, cloning, and sequence analysis of the wheat germ enzyme", BIOCHEMISTRY, vol. 32, 1993, pages 11100-11111, XP000867677
  • See also references of WO 9612797A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9612797 A1 19960502; AU 4134196 A 19960515; CA 2203265 A1 19960502; EP 0796322 A1 19970924; EP 0796322 A4 20000426; JP H10507919 A 19980804

INPADOC legal status


2003-01-02 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020501

2000-04-26 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20000309

2000-04-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

2000-04-05 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7C 12N 9/10 A, 7C 12N 15/63 B, 7C 12N 15/82 B, 7C 12P 21/06 B, 7A 61K 38/51 B

1997-09-24 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19970509

1997-09-24 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE