EP 0796332 A1 19970924 - NEISSERIA MENINGITIDIS SUBUNIT TBP2

Title (en)

NEISSERIA MENINGITIDIS SUBUNIT TBP2

Title (de)

NEISSERIA MENINGITIDIS UNTEREINHEIT TBP2

Title (fr)

SOUS-UNITE TBP2 DE NEISSERIA MENINGITIDIS

Publication

EP 0796332 A1 19970924 (FR)

Application

EP 96933511 A 19961010

Priority

FR 9601580 W 19961010
FR 9512106 A 19951010

Abstract (en)

[origin: FR2739624A1] A substantially purified protein, i.e. the lower molecular weight subunit (Tbp2) of the human transferrin receptor (HTR) of an N. meningitidis strain characterised in that it is not recognised in a dot blot assay by an antiserum to a polypeptide that corresponds to the Tbp2 of N. meningitidis strain M982 (Tbp2 M982) deleted from the hypervariable portions of the second domain. The Tbp2 subunit is characterised (i) in that it is encoded by a DNA fragment of around 2.1 kb, and (ii) in that it has an M982-type hinge region. Said Tbp2 subunit and the polypeptide fragments derived therefrom are particularly useful as vaccines, especially when combined with known N. meningitidis Tbp2 subunits. DNA fragments coding for the novel Tbp2 and derived polypeptides are also disclosed.

IPC 1-7

C12N 15/31; C07K 14/22; C07K 14/705; C07K 16/12; A61K 39/095

IPC 8 full level

A61K 35/74 (2006.01); A61K 39/095 (2006.01); A61P 31/04 (2006.01); C07K 14/22 (2006.01); C12N 15/09 (2006.01); C12N 15/31 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A61P 31/04 (2018.01); C07K 14/22 (2013.01); A61K 38/00 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

FR 2739624 A1 19970411; FR 2739624 B1 19971205; AU 720789 B2 20000615; AU 7221396 A 19970430; CA 2207302 A1 19970417; EP 0796332 A1 19970924; HU P9801714 A2 19981028; HU P9801714 A3 20000328; JP H11500630 A 19990119; NO 972314 D0 19970521; NO 972314 L 19970718; WO 9713860 A1 19970417

DOCDB simple family (application)

FR 9512106 A 19951010; AU 7221396 A 19961010; CA 2207302 A 19961010; EP 96933511 A 19961010; FR 9601580 W 19961010; HU P9801714 A 19961010; JP 51477397 A 19961010; NO 972314 A 19970521