EP 0797453 B1 20030326 - COMPOSITION FOR TREATMENT OF MALIGNANT TUMORS AND THEIR METASTASES
Title (en)
COMPOSITION FOR TREATMENT OF MALIGNANT TUMORS AND THEIR METASTASES
Title (de)
ZUSAMMENSETZUNG FÜR BEHANDLUNG VON MALIGNER TUMORE UND IHRE METASTASE
Title (fr)
COMPOSITION POUR LE TRAITEMENT DE TUMEURS MALIGNES ET DE LEURS METASTASES
Publication
Application
Priority
- US 9515097 W 19951127
- US 36035294 A 19941221
Abstract (en)
[origin: US5639737A] Growth or metastasization of malignant tumors can be inhibited by administering to a patient in need thereof sufficient lactose to block crucial lectins on the affected organ so that the tumor cells cannot anchor to other locations in the body. Lactose can be administered alone, or in combination with conjugates of cytotoxic drugs. Preferably, lactose is conjugated to a cytotoxic substance so that the primary tumor is treated concurrently with prevention of metastasis. Additionally, by conjugating a cytotoxic drug to lactose, the cytotoxic drug is maintained in close proximity to the tumor because of the receptors on the tumor which bind the lactose (and therefore the cytotoxic agent bound thereto) to the tumor cells. By using a conjugate of lactose with a cytotoxic agent, one dose is generally sufficient to destroy the receptor sites on the tumor and prevent metastasis of the tumor while treating the tumor.
IPC 1-7
IPC 8 full level
A61K 31/05 (2006.01); A61K 31/085 (2006.01); A61K 31/165 (2006.01); A61K 31/195 (2006.01); A61K 31/235 (2006.01); A61K 31/70 (2006.01)
CPC (source: EP US)
A61K 31/05 (2013.01 - EP US); A61K 31/085 (2013.01 - EP US); A61K 31/165 (2013.01 - EP US); A61K 31/195 (2013.01 - EP US); A61K 31/235 (2013.01 - EP US); A61K 31/70 (2013.01 - EP US); A61K 47/549 (2017.08 - EP US); A61P 35/04 (2018.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9619243 A1 19960627; AT E235257 T1 20030415; AU 4240796 A 19960710; AU 692021 B2 19980528; CA 2208206 A1 19960627; CA 2208206 C 20080212; DE 69530109 D1 20030430; DE 69530109 T2 20040205; EP 0797453 A1 19971001; EP 0797453 B1 20030326; IL 116465 A0 19960331; IL 116465 A 20100429; MX 9704727 A 19980630; US 5639737 A 19970617
DOCDB simple family (application)
US 9515097 W 19951127; AT 95940764 T 19951127; AU 4240796 A 19951127; CA 2208206 A 19951127; DE 69530109 T 19951127; EP 95940764 A 19951127; IL 11646595 A 19951220; MX 9704727 A 19970623; US 36035294 A 19941221