EP 0797583 A1 19971001 - TACHYKININ ANTAGONISTS
Title (en)
TACHYKININ ANTAGONISTS
Title (de)
TACHYKININ-ANTAGONISTEN
Title (fr)
ANTAGONISTES DE LA TACHYKININE
Publication
Application
Priority
- EP 9504910 W 19951212
- GB 9425085 A 19941213
- GB 9426016 A 19941222
Abstract (en)
[origin: WO9618643A1] Compounds of formula (I), wherein R1 is mono- or di-substituted phenyl, n is zero or 1, X1 is oxygen, sulfur or =NCN, X2 and X3 are oxygen or sulfur, R2 is hydrogen or methyl, R3 is phenyl, halo-substituted phenyl, 2-naphthyl, IH-indol-3-yl or 1-methyl-indol-3-yl, Z is -N(CH3)- or -CH2-, R4 is phenyl, 3,5-bis(trifluoromethyl)phenyl or pyridyl and R5 is hydrogen, phenyl 3,5-bis(trifluoromethyl)phenyl or pyridyl, whereby, when X3 is sulfur, Z is -N(CH3)- and acid addition salt thereof have tachykinin antagonist activity and are useful as pharmaceuticals, e.g. for the treatment of pain.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61P 25/04 (2006.01); A61P 29/00 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 411/12 (2006.01); C07K 1/113 (2006.01); C07K 5/078 (2006.01)
CPC (source: EP)
A61P 25/04 (2017.12); A61P 29/00 (2017.12); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 411/12 (2013.01); C07K 5/06165 (2013.01)
Citation (search report)
See references of WO 9618643A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9618643 A1 19960620; AR 001332 A1 19971022; AU 4343796 A 19960703; BR 9509997 A 19971230; CA 2204130 A1 19960620; CO 4700289 A1 19981229; CZ 179097 A3 19971015; EP 0797583 A1 19971001; FI 971685 A0 19970418; FI 971685 A 19970813; HU T77002 A 19980302; IL 116323 A0 19960331; JP H10511935 A 19981117; MX 9703957 A 19970930; NO 972526 D0 19970603; NO 972526 L 19970603; PE 38997 A1 19971002; PL 320217 A1 19970915; SK 74697 A3 19971105; TR 199501568 A2 19960721
DOCDB simple family (application)
EP 9504910 W 19951212; AR 33458995 A 19951213; AU 4343796 A 19951212; BR 9509997 A 19951212; CA 2204130 A 19951212; CO 95058767 A 19951212; CZ 179097 A 19951212; EP 95942131 A 19951212; FI 971685 A 19970418; HU 9701897 A 19951212; IL 11632395 A 19951211; JP 51826196 A 19951212; MX 9703957 A 19951212; NO 972526 A 19970603; PE 28685995 A 19951211; PL 32021795 A 19951212; SK 74697 A 19951212; TR 9501568 A 19951213