Title (en)

A PROCESS FOR THE PREPARATION OF SUBSTITUTED 4-ETHYL-PIPERIDINES AND AN INTERMEDIATE FOR THE PREPARATION OF SAME

Title (de)

VERFAHREN ZUR HERSTELLUNG VON SUBSTITUIERTEN 4-ETHYLPIPERIDINEN SOWIE DAFÜR BENÖTIGTE INTERMEDIATE

Title (fr)

PROCEDE DE PREPARATION DE 4-ETHYL-PIPERIDINES SUBSTITUEES ET INTERMEDIAIRE POUR LEUR PREPARATION

Publication

EP 0799201 A1 19971008 (EN)

Application

EP 95941716 A 19951215

Priority

• DK 145594 A 19941221
• EP 9504975 W 19951215

Abstract (en)

[origin: WO9619452A1] The invention relates to a process for the preparation of substituted 4-ethyl-piperidines having formula (I), or a salt thereof, wherein R is (aryl)palkyl, (aryl)palkenyl or (aryl)palkynyl, wherein the aryl groups may be substituted; cycloalkyl; or cycloalkylalkyl; p is 0, 1 or 2; m is 0, 1, 2, 3, 4, 5 or 6; A is O, S or NR<1>, wherein R<1> is hydrogen, alkyl or phenylalkyl; an Ar is aryl or heteroaryl, each of which may be substituted; which comprises the step of reacting a quinuclidinium salt of formula (a), wherein R is as defined above and Y is a counter ion, with a compound of the formula: HA-(CH2)m-Ar or a reactive derivative thereof, and thereafter optionally forming a salt thereof.

IPC 1-7

C07D 211/22; C07D 453/02

IPC 8 full level

C07D 211/22 (2006.01); C07D 453/02 (2006.01)

CPC (source: EP US)

C07D 211/22 (2013.01 - EP US); C07D 453/02 (2013.01 - EP US)

Citation (search report)

See references of WO 9619452A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9619452 A1 19960627; AT E206113 T1 20011015; AU 4304596 A 19960710; DE 69522960 D1 20011031; DE 69522960 T2 20020328; EP 0799201 A1 19971008; EP 0799201 B1 20010926; FI 972530 A0 19970613; FI 972530 A 19970813; US 5892047 A 19990406

DOCDB simple family (application)

EP 9504975 W 19951215; AT 95941716 T 19951215; AU 4304596 A 19951215; DE 69522960 T 19951215; EP 95941716 A 19951215; FI 972530 A 19970613; US 84985297 A 19970804