EP 0799240 A1 19971008 - HETEROCYCLIC KETO ARGININE PEPTIDES AS THROMBIN INHIBITORS
Title (en)
HETEROCYCLIC KETO ARGININE PEPTIDES AS THROMBIN INHIBITORS
Title (de)
HETEROZYKLISCHE KETO ARGININ PEPTIDE ALS THROMBIN-INHIBITOREN
Title (fr)
PEPTIDES DE CETOARGININE HETEROCYCLIQUES UTILISES COMME INHIBITEURS DE THROMBINE
Publication
Application
Priority
- CA 9500711 W 19951221
- GB 9426038 A 19941222
- GB 9503136 A 19950217
- GB 9504404 A 19950306
- GB 9504403 A 19950306
Abstract (en)
[origin: WO9619491A1] This invention relates to new and useful inhibitors of the enzyme thrombin of the formula (I): AS - X, and more particularly compound (1) in the preparation, and pharmaceutical compositions. As well, this invention relates to the use of such compounds and compositions in vitro as anticoagulants and in vivo as agents for the treatment and prophylaxis of thrombotic disorders such as venous thrombosis, pulmonary embolism and arterial thrombosis resulting in acute ischemic events such as myocardial infarction or cerebral infarction. Moreover, these compounds and compositions have therapeutic utility for the prevention and treatment of coagulopathis associated with coronary bypass operations as well as restenotic events following transluminal angioplasty.
IPC 1-7
IPC 8 full level
C07D 417/12 (2006.01); A61K 31/425 (2006.01); A61P 7/02 (2006.01); C07K 5/065 (2006.01); C07K 5/087 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 7/02 (2017.12); C07K 5/06078 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9619491A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9619491 A1 19960627; AU 4062795 A 19960627; AU 4250896 A 19960710; AU 699679 B2 19981210; CA 2208773 A1 19960627; EP 0799240 A1 19971008; IL 116502 A0 19960331; JP H10513151 A 19981215; MX 9704594 A 19980731
DOCDB simple family (application)
CA 9500711 W 19951221; AU 4062795 A 19951222; AU 4250896 A 19951221; CA 2208773 A 19951221; EP 95940926 A 19951221; IL 11650295 A 19951222; JP 51938596 A 19951221; MX 9704594 A 19970619