Global Patent Index - EP 0799305 A4

EP 0799305 A4 20000126 - TRANSGENIC ANIMAL LACKING NATIVE AMYLOID PRECURSOR PROTEIN

Title (en)

TRANSGENIC ANIMAL LACKING NATIVE AMYLOID PRECURSOR PROTEIN

Title (de)

TRANSGENES TIER MIT MANGEL AN AMYLOIDEN VORLÄUFERPROTEIN

Title (fr)

ANIMAL TRANSGENIQUE PRESENTANT UNE CARENCE EN PROTEINE PRECURSEUR D'AMYLOIDE NATIVE

Publication

EP 0799305 A4 20000126 (EN)

Application

EP 95942534 A 19951201

Priority

  • US 9515672 W 19951201
  • US 34933494 A 19941205

Abstract (en)

[origin: WO9617926A1] The present invention relates to a transgenic nonhuman animal lacking native amyloid precursor protein. The transgenic mouse of the invention may be used in the study of Alzheimer's Disease and disorders involving the central nervous system.

IPC 1-7

C12N 5/00; C12N 15/00; C12N 15/63

IPC 8 full level

C12N 15/09 (2006.01); A01K 67/027 (2006.01); C07K 14/47 (2006.01); C12N 5/10 (2006.01); C12N 15/85 (2006.01)

CPC (source: EP)

A01K 67/0276 (2013.01); C07K 14/4711 (2013.01); C12N 15/8509 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0312 (2013.01); C12N 2517/02 (2013.01)

Citation (search report)

  • [X] WO 9314200 A1 19930722 - TSI CORP [US]
  • [X] MUCKE L. ET AL.: "Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice", BRAIN RESEARCH, vol. 666, no. 2, 1994, pages 151 - 167, XP002121613
  • [X] LANNFELT L. ET AL.: "Alzheimer's disease: molecular genetics and transgenic animal models", BEHAVIOURAL BRAIN RESEARCH, vol. 57, no. 2, 1993, pages 207 - 213, XP002121614

Citation (examination)

  • S. L. Mansour et al., 1988, "Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes", Nature, vol. 336 pages 348-352.
  • T. Yamada et al., 1987, "Complementary DNA for the mouse homolog of the human amyloid beta protein precursor", Biochemical and Biophysical Research Communication, vol. 149, pages 665-671.
  • G. Wright et al., 1991, "High level expression of active human alpha-1-antitrypsin in the milk of transgenic sheep", Biotechnology, vol. 9, pages 830-834.
  • See also references of WO 9617926A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9617926 A1 19960613; CA 2206789 A1 19960613; EP 0799305 A1 19971008; EP 0799305 A4 20000126; JP 2000504202 A 20000411

DOCDB simple family (application)

US 9515672 W 19951201; CA 2206789 A 19951201; EP 95942534 A 19951201; JP 51767596 A 19951201