EP 0800391 A1 19971015 - BENZIMIDAZOLES AS INHIBITORS OF CALCITRIOL METABOLISM
Title (en)
BENZIMIDAZOLES AS INHIBITORS OF CALCITRIOL METABOLISM
Title (de)
BENZIMIDAZOLE ZUR HEMMUNG DES CALCITRIOL-METABOLISMUS
Title (fr)
BENZIMIDAZOLES UTILISES COMME INHIBITEURS DU METABOLISME DU CALCITRIOL
Publication
Application
Priority
- EP 95943236 A 19951221
- EP 9505172 W 19951221
- EP 94203774 A 19941228
Abstract (en)
[origin: WO9619991A1] The invention relates to the use of a (1H-imidazol-1-yl)methyl-1H-benzimidazole, a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, for the manufacture of a medicament for treating a pathological condition which is beneficially influenced by inhibiting the metabolic degradation of calcitriol, said benzimidazole having formula (I), wherein R is hydrogen; C1-10alkyl; C3-7cycloalkyl; Ar<1> or Ar<1>-C1-6alkyl; R<1> is hydrogen; C3-7cycloalkyl; Ar<1>; C1-10alkyl; C1-6alkyl substituted with Ar<1> or C3-7cycloalkyl; hydroxy; C1-10alkyloxy; C1-6alkyloxy substituted with Ar<1> or C3-7cycloalkyl; C3-6alkenyloxy optionally substituted with Ar<2>; C3-6alkynyloxy optionally substituted with Ar<2>; or Ar<1>-oxy; R<2> is hydrogen; halo; C1-10alkyl; C1-4alkyl substituted with up to 4 halo atoms; C3-7cycloalkyl; Ar<1>; quinolinyl; indolinyl; C1-6alkyl substituted with Ar<1>, C3-7cycloalkyl, quinolinyl, indolinyl or hydroxy; C1-10alkyloxy; C1-6alkyloxy substituted with Ar<1> or C3-7cycloalkyl; C3-6alkenyl optionally substituted with Ar<1>; Ar<2>-oxy; C1-6alkyloxycarbonyl; carboxyl; C1-6alkylcarbonyl; Ar<1>-carbonyl or Ar<1>-(CHOH)-; compositions comprising calcitriol or a prodrug thereof and a compound of formula (I).
IPC 1-7
IPC 8 full level
C07D 403/06 (2006.01); A61K 31/415 (2006.01); A61K 31/4184 (2006.01); A61P 3/02 (2006.01); A61P 3/08 (2006.01); A61P 9/12 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01)
CPC (source: EP)
A61K 31/4184 (2013.01); A61P 3/02 (2017.12); A61P 3/08 (2017.12); A61P 9/12 (2017.12); A61P 29/00 (2017.12); A61P 35/00 (2017.12); A61P 37/00 (2017.12)
Citation (search report)
See references of WO 9619991A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9619991 A1 19960704; AU 4436196 A 19960719; EP 0800391 A1 19971015; JP H10511653 A 19981110
DOCDB simple family (application)
EP 9505172 W 19951221; AU 4436196 A 19951221; EP 95943236 A 19951221; JP 52022196 A 19951221