EP 0801649 B1 20020807 - HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE MOLECULAR CHAPERON PRODUCTION AND THE PREPARATION THEREOF
Title (en)
HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE MOLECULAR CHAPERON PRODUCTION AND THE PREPARATION THEREOF
Title (de)
HYDROXYLAMIN DERIVATE VERWENDBAR FÜR DIE VERBESSERUNG DER ERZEUGUNG VON MOLEKULAREN KAPPEN UND DEREN HERSTELLUNG
Title (fr)
DERIVES D'HYDROXYLAMINE UTILISES POUR AMELIORER LA PRODUCTION DE CHAPERONS MOLECULAIRES ET LEUR PREPARATION.
Publication
Application
Priority
- HU 9503141 A 19951102
- HU 9603919 A 19960209
- HU 9629820 A 19961004
- HU 9600064 W 19961101
Abstract (en)
[origin: WO9716439A1] A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, a hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which a hydroxylamine derivative is administered is a eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.
IPC 1-7
C07D 333/38; C07D 215/54; C07D 307/68; C07D 213/78; C07D 213/89; C07D 217/26; C07D 413/04; C07D 295/08; C07C 259/02; A61K 31/44
IPC 8 full level
A61K 31/15 (2006.01); A61K 31/133 (2006.01); A61K 31/34 (2006.01); A61K 31/341 (2006.01); A61K 31/44 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/445 (2006.01); A61K 31/47 (2006.01); A61K 31/472 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61P 9/00 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 25/00 (2006.01); A61P 25/18 (2006.01); A61P 25/28 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61P 37/08 (2006.01); C07C 215/00 (2006.01); C07C 259/02 (2006.01); C07C 259/18 (2006.01); C07C 275/64 (2006.01); C07C 279/18 (2006.01); C07D 213/78 (2006.01); C07D 213/81 (2006.01); C07D 213/89 (2006.01); C07D 215/16 (2006.01); C07D 215/54 (2006.01); C07D 217/22 (2006.01); C07D 217/26 (2006.01); C07D 271/06 (2006.01); C07D 295/08 (2006.01); C07D 295/088 (2006.01); C07D 295/22 (2006.01); C07D 307/68 (2006.01); C07D 333/38 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/04 (2006.01); C12N 5/04 (2006.01); C12N 5/07 (2010.01); C12N 5/071 (2010.01); C12N 5/0793 (2010.01); C12N 15/67 (2006.01); C12P 21/00 (2006.01); C12R 1/91 (2006.01)
IPC 8 main group level
CPC (source: EP KR US)
A61P 1/04 (2017.12 - EP); A61P 7/00 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/02 (2017.12 - EP); A61P 9/08 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 11/16 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 17/02 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 31/04 (2017.12 - EP); A61P 31/12 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/08 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07C 259/02 (2013.01 - EP KR US); C07C 259/18 (2013.01 - EP KR US); C07C 275/64 (2013.01 - EP US); C07C 279/18 (2013.01 - EP US); C07D 213/78 (2013.01 - EP KR US); C07D 213/89 (2013.01 - EP KR US); C07D 215/54 (2013.01 - EP KR US); C07D 217/26 (2013.01 - EP KR US); C07D 295/088 (2013.01 - EP KR US); C07D 307/68 (2013.01 - EP KR US); C07D 333/38 (2013.01 - EP KR US); C07D 409/12 (2013.01 - EP KR US); C07D 413/04 (2013.01 - EP KR US); C07C 2601/14 (2017.04 - EP US)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9716439 A1 19970509; AT E221880 T1 20020815; AU 720195 B2 20000525; AU 7326396 A 19970522; BG 101713 A 19980331; BG 63944 B1 20030731; BR 9607565 A 19990720; BR 9607565 B1 20110823; CA 2209167 A1 19970509; CA 2209167 C 20090519; CN 1152871 C 20040609; CN 1177351 A 19980325; CZ 207297 A3 19980318; CZ 295562 B6 20050817; DE 69622840 D1 20020912; DE 69622840 T2 20030430; DK 0801649 T3 20021202; EE 04239 B1 20040216; EE 9700146 A 19971215; EP 0801649 A2 19971022; EP 0801649 B1 20020807; ES 2176502 T3 20021201; HR P960508 A2 19980630; HR P960508 B1 20041031; HU 222994 B1 20040128; HU 9503141 D0 19951228; HU T76659 A 19971028; IL 121126 A0 19971120; IL 121126 A 20020725; JP 2009108048 A 20090521; JP 4531865 B2 20100825; JP H10512590 A 19981202; KR 19980700976 A 19980430; MX 9704988 A 19980731; NO 321140 B1 20060327; NO 973059 D0 19970701; NO 973059 L 19970902; NZ 320523 A 20010525; PL 195634 B1 20071031; PL 322015 A1 19980105; PT 801649 E 20021231; RS 49981 B 20080929; RU 2206320 C2 20030620; SI 0801649 T1 20021231; SK 284823 B6 20051201; SK 88197 A3 19980408; TR 199700574 T1 19990823; UA 61050 C2 20031117; US 2004019103 A1 20040129; US 2004067940 A1 20040408; US 2010267711 A1 20101021; US 6653326 B1 20031125; US 7148239 B2 20061212; US 7745465 B2 20100629; YU 58796 A 19990927; ZA 969249 B 19980302
DOCDB simple family (application)
HU 9600064 W 19961101; AT 96935195 T 19961101; AU 7326396 A 19961101; BG 10171397 A 19970701; BR 9607565 A 19961101; CA 2209167 A 19961101; CN 96192305 A 19961101; CZ 207297 A 19961101; DE 69622840 T 19961101; DK 96935195 T 19961101; EE 9700146 A 19961101; EP 96935195 A 19961101; ES 96935195 T 19961101; HR P960508 A 19961031; HU 9503141 A 19951102; IL 12112696 A 19961101; JP 2008261964 A 20081008; JP 51717697 A 19961101; KR 97070004575 A 19970702; MX 9704988 A 19961101; NO 973059 A 19970701; NZ 32052396 A 19961101; PL 32201596 A 19961101; PT 96935195 T 19961101; RU 97113758 A 19961101; SI 9630518 T 19961101; SK 88197 A 19961101; TR 9700574 T 19961101; UA 97084081 A 19961101; US 61815703 A 20030710; US 61816203 A 20030710; US 82382310 A 20100625; US 86058299 A 19991207; YU 58796 A 19961101; ZA 969249 A 19961104