EP 0802916 A1 19971029 - LOW MOLECULAR WEIGHT BICYCLIC THROMBIN INHIBITORS
Title (en)
LOW MOLECULAR WEIGHT BICYCLIC THROMBIN INHIBITORS
Title (de)
NIEDERMOLEKULARE BIZYKLISCHE THROMBIN-INHIBITOREN
Title (fr)
INHIBITEURS DE LA THROMBINE BICYCLIQUE A FAIBLE POIDS MOLECULAIRE
Publication
Application
Priority
- CA 9500708 W 19951221
- GB 9426038 A 19941222
- GB 9503136 A 19950217
- GB 9510265 A 19950522
- GB 9510267 A 19950522
- GB 9510266 A 19950522
Abstract (en)
[origin: WO9619483A1] This invention relates to the discovery of heterocyclic competitive inhibitors of the enzyme thrombin having formula (I), their preparation, and pharmaceutical compositions thereof. As well, this invention relates to the use of such compounds and compositions in vitro as anticoagulants and in vivo as agents for the treatment and prophylaxis of thrombotic disorders such as venous thrombosis, pulmonary embolism and arterial thrombosis resulting in acute ischemic events such as myocardial infarction or cerebral infarction. Moreover, these compounds and compositions have therapeutic utility for the prevention and treatment of coagulopathies associated with coronary bypass operations as well as restenotic events following transluminal angioplasty.
IPC 1-7
IPC 8 full level
A61K 31/435 (2006.01); A61K 31/445 (2006.01); A61K 31/47 (2006.01); A61K 31/495 (2006.01); A61K 31/54 (2006.01); A61P 7/02 (2006.01); A61P 9/00 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); C07D 487/04 (2006.01); C07D 513/04 (2006.01); C07K 5/02 (2006.01); C07K 5/065 (2006.01); C07K 5/078 (2006.01); C07K 5/087 (2006.01); C07K 5/097 (2006.01); A61K 38/00 (2006.01)
IPC 8 main group level
CPC (source: EP)
A61P 7/02 (2017.12); A61P 9/00 (2017.12); A61P 9/08 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); C07D 487/04 (2013.01); C07D 513/04 (2013.01); C07K 5/0202 (2013.01); C07K 5/06078 (2013.01); C07K 5/06139 (2013.01); C07K 5/0812 (2013.01); C07K 5/0821 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9619483A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9619483 A1 19960627; AP 9701004 A0 19970731; AU 4062895 A 19960704; AU 4250596 A 19960710; AU 715378 B2 20000203; BG 101647 A 19980331; CA 2208772 A1 19960627; CN 1175259 A 19980304; CZ 189997 A3 19980916; EE 9700113 A 19971215; EP 0802916 A1 19971029; FI 972466 A0 19970611; FI 972466 A 19970819; HU T77651 A 19980728; IL 116503 A0 19960331; IS 4504 A 19970611; JP H11508535 A 19990727; LV 12019 A 19980420; LV 12019 B 19980720; MD 970253 A 19990531; MX 9704718 A 19980628; NO 972892 D0 19970620; NO 972892 L 19970820; NZ 297360 A 20000327; OA 10493 A 20020410; PL 320965 A1 19971124; SK 83897 A3 19980506
DOCDB simple family (application)
CA 9500708 W 19951221; AP 9701004 A 19951221; AU 4062895 A 19951222; AU 4250596 A 19951221; BG 10164797 A 19970620; CA 2208772 A 19951221; CN 95197614 A 19951221; CZ 189997 A 19951221; EE 9700113 A 19951221; EP 95940923 A 19951221; FI 972466 A 19970611; HU 9800216 A 19951221; IL 11650395 D 19951222; IS 4504 A 19970611; JP 51938396 A 19951221; LV 970141 A 19970715; MD 970253 A 19951221; MX 9704718 A 19970623; NO 972892 A 19970620; NZ 29736095 A 19951221; OA 70029 A 19970618; PL 32096595 A 19951221; SK 83897 A 19951221