Global Patent Index - EP 0803501 B1

EP 0803501 B1 2000-07-05 - Substituted guanidine derivatives and their use as Na+/H+ exchange inhibitors

Title (en)

Substituted guanidine derivatives and their use as Na+/H+ exchange inhibitors

Title (de)

Substituierte Guanidin Derivate und ihre Verwendung als Na+/H+ Austausch Inhibitoren

Title (fr)

Dérivés de guanidine substituées et leur utilisation comme inhibiteurs de l'échange Na+/H+

Publication

EP 0803501 B1 (EN)

Application

EP 97302773 A

Priority

JP 12897396 A

Abstract (en)

[origin: EP0803501A1] Substituted guanidine derivatives of formula (1) <CHEM> wherein each of R1 to R4 and Z is an organic group, m is 0, 1 or 2 and Y1, Y2, Y3 and Y4 form, together with the carbon atoms to which they are attached, a saturated or unsaturated carbocyclic or heterocyclic ring; and pharmaceutically acceptable salts thereof; are inhibitors of the sodium/proton (Na<+>/H<+>) exchange transport system and can therefore be used in the treatment or prophylaxis of, for example, hypertension, arrhythmia, angina pectoris, cardiac hypertrophy, diabetes mellitus, organ disorders associated with ischemia or ischemic reperfusion, cerebroischemic disorders, diseases caused by excessive cell proliferation, and diseases caused by endothelia cell injury.

IPC 1-7 (main, further and additional classification)

C07D 209/90; A61K 31/40; C07D 209/94

IPC 8 full level (invention and additional information)

C07D 401/12 (2006.01); A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/4427 (2006.01); A61K 31/445 (2006.01); A61P 1/16 (2006.01); A61P 3/08 (2006.01); A61P 9/00 (2006.01); A61P 9/06 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 11/00 (2006.01); A61P 13/02 (2006.01); A61P 15/00 (2006.01); A61P 25/28 (2006.01); C07D 209/90 (2006.01); C07D 209/94 (2006.01); C07D 403/12 (2006.01)

CPC (invention and additional information)

C07D 209/94 (2013.01); C07D 209/90 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

DOCDB simple family

EP 0803501 A1 19971029; EP 0803501 B1 20000705; AT 194327 T 20000715; DE 69702419 D1 20000810; DE 69702419 T2 20001214; ES 2147966 T3 20001001; JP H09291076 A 19971111; US 5814654 A 19980929