EP 0804218 A1 19971105 - PRODUCT AND PROCESS FOR REGULATING SIGNAL TRANSDUCTION PATHWAYS
Title (en)
PRODUCT AND PROCESS FOR REGULATING SIGNAL TRANSDUCTION PATHWAYS
Title (de)
Produkt und Verfahren zur Regulierung von Signalübertragungswegen
Title (fr)
PRODUIT ET PROCEDE DE REGULATION DES VOIES DE TRANSDUCTION DE SIGNAUX
Publication
Application
Priority
- US 9503438 W 19950317
- US 21511694 A 19940317
Abstract (en)
[origin: WO9524915A1] Products and processes are disclosed for regulating signal transduction pathways in cells. One aspect of the invention relates to a peptide having a YXXLXXXXXXXYXX psi amino acid motif that is useful in regulating the activity of tyrosine kinases, lipid kinases and adaptor molecules. A separate aspect of the present invention relates to a product and process for inhibiting signal transduction pathways in cells involving a peptide capable of binding to an SH3 domain of a tyrosine kinase, thereby blocking the binding and activation of an effector by the tyrosine kinase. Both the above compound and peptide composition can be useful in the treatment of medical disorders such as allergic responses, autoimmune diseases, inflammatory responses, cancer, immunodeficiency diseases, immunoproliferative diseases and diseases caused by viruses, such as EBV and BLV.
IPC 1-7
IPC 8 full level
A61K 9/127 (2006.01); A61K 35/12 (2006.01); A61K 35/64 (2006.01); A61K 35/74 (2006.01); A61K 36/00 (2006.01); A61K 36/06 (2006.01); A61K 38/00 (2006.01); A61K 38/08 (2006.01); A61K 38/17 (2006.01); A61K 38/45 (2006.01); A61K 38/55 (2006.01); A61K 48/00 (2006.01); A61P 3/08 (2006.01); A61P 29/00 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61P 37/02 (2006.01); A61P 37/04 (2006.01); A61P 37/06 (2006.01); C07H 21/04 (2006.01); C07K 7/08 (2006.01); C07K 14/05 (2006.01); C07K 14/15 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 14/735 (2006.01); C12N 5/06 (2006.01); C12N 5/07 (2010.01); C12N 5/071 (2010.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01)
CPC (source: EP)
A61P 3/08 (2017.12); A61P 29/00 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 37/00 (2017.12); A61P 37/02 (2017.12); A61P 37/04 (2017.12); A61P 37/06 (2017.12); C07K 7/08 (2013.01); C07K 14/005 (2013.01); C07K 14/705 (2013.01); C07K 14/7051 (2013.01); C07K 14/70535 (2013.01); A61K 38/00 (2013.01); C12N 2710/16222 (2013.01); C12N 2740/14022 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9524915 A1 19950921; AU 2187495 A 19951003; AU 699662 B2 19981210; CA 2184631 A1 19950921; EP 0804218 A1 19971105; EP 0804218 A4 19971112; JP H09512704 A 19971222
DOCDB simple family (application)
US 9503438 W 19950317; AU 2187495 A 19950317; CA 2184631 A 19950317; EP 95914756 A 19950317; JP 52421095 A 19950317