EP 0804453 A4 20040811 - METHOD FOR DETECTION AND TREATMENT OF BREAST CANCER
Title (en)
METHOD FOR DETECTION AND TREATMENT OF BREAST CANCER
Title (de)
VERFAHREN ZUM NACHWEIS UND ZUR BEHANDLUNG VON BRUSTKREBS
Title (fr)
PROCEDE DE DETECTION ET DE TRAITEMENT DU CANCER DU SEIN
Publication
Application
Priority
- US 9500608 W 19950117
- US 37379995 A 19950117
Abstract (en)
[origin: CA2210396A1] The present invention provides a method of detecting and diagnosing pre-invasive breast cancer by identifying differentially expressed genes in early, pre-invasive breast cancer tissue. Differentially expressed genes can be used as genetic markers to indicate the presence of pre-invasive cancerous tissues. Microscopically directed tissue sampling techniques combined with differential display or differential screening of cDNA libraries are used to determine differential expression of genes in the early stages of breast cancer. Differential expression of genes in pre-invasive breast cancer tissue is confirmed by RT-PCR, nuclease protection assays and in-situ hybridization of ductal carcinoma in situ tissue RNA and control tissue RNA. The present invention also provides a method of screening for compounds that induce expression of the BRCA1 gene, whose product negatively regulates cell growth in both normal and malignant mammary epithlial cells. The present invention also relates to gene therapy method using this gene.
IPC 1-7
IPC 8 full level
A61K 31/70 (2006.01); A61K 48/00 (2006.01); C07H 21/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C07K 7/04 (2006.01); C07K 14/47 (2006.01); C07K 14/82 (2006.01); C07K 16/18 (2006.01); C07K 16/40 (2006.01); C12N 9/02 (2006.01); C12N 15/12 (2006.01); C12N 15/53 (2006.01); C12N 15/63 (2006.01); C12N 15/85 (2006.01); C12P 21/00 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/53 (2006.01); G01N 33/574 (2006.01)
CPC (source: EP US)
C07K 14/82 (2013.01 - EP); C12Q 1/6886 (2013.01 - EP); G01N 33/57415 (2013.01 - EP US); C12Q 2600/112 (2013.01 - EP); C12Q 2600/136 (2013.01 - EP); C12Q 2600/158 (2013.01 - EP)
Citation (search report)
- [X] WO 9416080 A1 19940721 - EXEMPLAR CORP [US]
- [X] WO 9406910 A1 19940331 - CANJI INC [US], et al
- [E] EP 0705903 A1 19960410 - MYRIAD GENETICS INC [US], et al
- [A] KUMAR C C: "SETTING UP REPORTER-GENE BASED ASSAY SYSTEMS FOR SCREENING ANTINEOPLASTIC DRUGS", PHARMACEUTICAL TECHNOLOGY, EUGENE, OR, US, vol. 15, June 1991 (1991-06-01), pages 26 - 28,32-34, XP009010062
- [DA] BROWN M A ET AL: "Regulation of BRCA1.", NATURE. ENGLAND 1994 DEC 22-29, vol. 372, no. 6508, 22 December 1994 (1994-12-22), pages 733, XP002283560, ISSN: 0028-0836
- [T] THOMPSON M E ET AL: "DECREASED EXPRESSION OF BRCA1 ACCELERATES GROWTH AND IS OFTEN PRESENT DURING SPORADIC BREAST CANCER PROGRESSION", NATURE GENETICS, NEW YORK, NY, US, vol. 9, no. 4, April 1995 (1995-04-01), pages 444 - 450, XP001011260, ISSN: 1061-4036
- See references of WO 9519369A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
AU 1831795 A 19950801; AU 707348 B2 19990708; CA 2210396 A1 19950720; EP 0804453 A1 19971105; EP 0804453 A4 20040811
DOCDB simple family (application)
AU 1831795 A 19950117; CA 2210396 A 19950117; EP 95910094 A 19950117