EP 0804487 A2 19971105 - BISPECIFIC ANTIGEN-BINDING MOLECULES
Title (en)
BISPECIFIC ANTIGEN-BINDING MOLECULES
Title (de)
BISPEZIFISCHE ANTIGENBINDENDE MOLEKUELE
Title (fr)
MOLECULES BISPECIFIQUES DE FIXATION D'ANTIGENES
Publication
Application
Priority
- US 9403171 W 19940321
- US 4596993 A 19930409
- US 16398893 A 19931207
Abstract (en)
[origin: WO9424163A2] The present invention relates to a class of molecules called "antigen forks" that inhibit cell growth. These antigen forks possess separate binding elements for two different cell surface antigens and are believed to heterologously crosslink the antigens by binding to them. The two antigens recognized by an antigen fork differ in at least one cellular functional quality, but are simultaneously expressed on the surface of at least one cell type targeted for killing or growth inhibition. Such targeted cells include tumor cells and virally-infected cells. It is preferred that the antigen fork be designed so that the two antigens it recognizes are seldom or never simultaneously expressed on normal cells. The antigen fork is preferably a bispecific antibody, but may also be constructed from binding elements that are not derived from antibodies. The present invention also relates to a hybrid hybridoma that produces an antigen fork and a method for treating a patient with cancer or a viral infection by administering an antigen fork. It is preferred that a cytotoxic agent such as deferoxamine or cisplatin is sequentially or simultaneously administered to the patient.
IPC 1-7
IPC 8 full level
A61K 31/16 (2006.01); A61K 33/24 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); C07K 16/08 (2006.01); C07K 16/30 (2006.01); C07K 16/46 (2006.01); C07K 19/00 (2006.01); C12N 5/10 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07K 16/30 (2013.01); C07K 16/468 (2013.01); A61K 38/00 (2013.01); C07K 2317/77 (2013.01)
Citation (search report)
See references of WO 9424163A2
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9424163 A2 19941027; WO 9424163 A3 19941208; AU 7241094 A 19941108; CA 2160224 A1 19941027; EP 0804487 A2 19971105; JP H08510116 A 19961029
DOCDB simple family (application)
US 9403171 W 19940321; AU 7241094 A 19940321; CA 2160224 A 19940321; EP 94921881 A 19940321; JP 52320294 A 19940321