Global Patent Index - EP 0804546 A4

EP 0804546 A4 2000-09-20 - HUMAN PROSTATIC SPECIFIC REDUCTASE

Title (en)

HUMAN PROSTATIC SPECIFIC REDUCTASE

Title (de)

MENSCHLICHE, PROSTATA-SPEZIFISCHE REDUKTASE

Title (fr)

REDUCTASE SPECIFIQUE DE LA PROSTATE CHEZ L'HOMME

Publication

EP 0804546 A4 (EN)

Application

EP 95911712 A

Priority

US 9501827 W

Abstract (en)

[origin: WO9622360A1] A human prostatic specific reductase polypeptide and polynucleotides encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides as a diagnostic marker for prostate cancer and as an agent to determine if the prostate cancer has metastasized. Also disclosed are antibodies specific to the prostatic specific reductase polypeptide which may be used to target prostate cancer cells and be used as part of a prostate cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also dislcosed.

IPC 1-7 (main, further and additional classification)

C12N 1/21; C07K 14/47; C12N 5/10; C12N 9/02; C12N 15/10; C12N 15/11; C12N 15/12; C12N 15/53; C12N 15/63; C12Q 1/26; C12Q 1/68

IPC 8 full level (invention and additional information)

G01N 33/50 (2006.01); C07K 16/40 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/02 (2006.01); C12N 15/00 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01); G01N 33/53 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); C12R 1/19 (2006.01); C12R 1/91 (2006.01)

CPC (invention and additional information)

C12N 9/0004 (2013.01); A61K 38/00 (2013.01); A61K 39/00 (2013.01)

Citation (search report)

  • [X] THIGPEN A E ET AL: "Molecular genetics of steroid 5 alpha-reductase 2 deficiency.", JOURNAL OF CLINICAL INVESTIGATION, (1992 SEP) 90 (3) 799-809., XP000087278
  • [T] AKALU A ET AL: "Somatic mutations at the SRD5A2 locus encoding prostatic steroid 5alpha-reductase during prostate cancer progression.", JOURNAL OF UROLOGY, (1999 APR) 161 (4) 1355-8., XP000881743
  • See also references of WO 9622360A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9622360 A1 19960725; AU 1918095 A 19960807; EP 0804546 A1 19971105; EP 0804546 A4 20000920; JP H10513044 A 19981215

INPADOC legal status


2005-06-08 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20041126

2004-01-02 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20031107

2000-09-20 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20000803

2000-09-20 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

1997-11-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19970818

1997-11-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE