EP 0805681 A4 19980506 - TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS
Title (en)
TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS
Title (de)
TOKOLYTISCHE OXYTOCIN-REZEPTOR-ANTAGONISTEN
Title (fr)
ANTAGONISTES TOCOLYTIQUES DES RECEPTEURS DE L'OXYTOCINE
Publication
Application
Priority
- US 9600850 W 19960119
- US 37811395 A 19950124
Abstract (en)
[origin: WO9622775A1] Compounds of formula (I) wherein X is selected from CH2 or O; provided that when R<1> and R<3> are both simultaneously hydrogen then (a) R<8> is C1-5 alkyl or halogen, and R<2> is C1-5 alkoxy, or (b) R<4> is (II); and the pharmaceutically acceptable salts thereof. Such compounds are useful in mammals as oxytocin receptor antagonists for the treatment of preterm labor, dysmenorrhea and stopping labor prior to cesarean delivery.
IPC 1-7
IPC 8 full level
C07D 401/14 (2006.01); C07D 413/04 (2006.01); C07D 413/14 (2006.01)
CPC (source: EP)
C07D 401/14 (2013.01); C07D 413/04 (2013.01); C07D 413/14 (2013.01)
Citation (search report)
- [E] WO 9725992 A1 19970724 - MERCK & CO INC [US], et al
- [A] EP 0470514 A1 19920212 - OTSUKA PHARMA CO LTD [JP]
- [A] WO 9401113 A1 19940120 - OTSUKA PHARMA CO LTD [JP], et al
- [A] EP 0043940 A1 19820120 - BOEHRINGER SOHN INGELHEIM [DE]
- [PX] PETTIBONE ET AL: "Progres in the development of oxytocin antagonists for use in preterm labor.", ADV.EXP.MED.BIOL., vol. 395, 1995, pages 601 - 612, XP002056092
- See references of WO 9622775A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9622775 A1 19960801; AU 4763896 A 19960814; CA 2210138 A1 19960801; EP 0805681 A1 19971112; EP 0805681 A4 19980506
DOCDB simple family (application)
US 9600850 W 19960119; AU 4763896 A 19960119; CA 2210138 A 19960119; EP 96903618 A 19960119