EP 0810882 A4 19990519 - METHODS AND COMPOSITIONS FOR REGULATION OF CD28 EXPRESSION
Title (en)
METHODS AND COMPOSITIONS FOR REGULATION OF CD28 EXPRESSION
Title (de)
VERFAHREN UND ZUSAMMENSETZUNG FÜR DIE REGULATION DER CD28-EXPRESSION
Title (fr)
METHODES ET COMPOSITIONS DE REGULATION DE L'EXPRESSION DE CD28
Publication
Application
Priority
- US 9601507 W 19960205
- US 38704195 A 19950209
Abstract (en)
[origin: WO9624380A1] Oligomers are provided which are capable of reducing CD28 gene in a T cell. In addition to specific sequences, the invention includes a class of oligomers having at least two sequences of GGGG separated by 3 to 5 bases. Targets include CD28 gene, 5' untranslated regions and initiation codon, and their respective transcripts. Methods include use of the oligomers to moderate the pathogenic effects on the immune system in immune system-mediated diseases including graft versus host disease, septic shock syndrome, viral diseases, psoriasis, Type I (insulin-dependent) diabetes mellitus, thyroiditis, sarcoidosis, multiple sclerosis, autoimmune uveitis, rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease.
IPC 1-7
IPC 8 full level
C12N 15/113 (2010.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
C12N 15/1138 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C12N 2310/111 (2013.01); C12N 2310/13 (2013.01); C12N 2310/151 (2013.01); C12N 2310/18 (2013.01); C12N 2310/315 (2013.01)
Citation (search report)
- [DA] TAM R C ET AL: "BIOLOGICAL AVAILABILITY AND NUCLEASE RESISTANCE EXTEND THE IN-VITRO ACTIVITY OF A PHOSPHOROTHIOATE-3'HYDROXYPROPYLAMINE OLIGONUCLEOTIDE", NUCLEIC ACIDS RESEARCH, (25 MAR 1994) VOL. 22, NO. 6, PP. 977-986., XP002096884
- [DA] MACAYA R F ET AL: "THROMBIN-BINDING DNA APTAMER FORMS A UNIMOLECULAR QUADRUPLEX STRUCTURE IN SOLUTION", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 90, April 1993 (1993-04-01), pages 3745 - 3749, XP002043117
- [T] TAM R C ET AL: "Oligonucleotide-mediated inhibition of CD28 expression induces human T cell hyporesponsiveness and manifests impaired contact hypersensitivity in mice.", JOURNAL OF IMMUNOLOGY, (1997 JAN 1) 158 (1) 200-8., XP002096885
- See also references of WO 9624380A1
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9624380 A1 19960815; EP 0810882 A1 19971210; EP 0810882 A4 19990519; HU P9801629 A2 19981028; HU P9801629 A3 20001030; PL 321711 A1 19971222
DOCDB simple family (application)
US 9601507 W 19960205; EP 96909477 A 19960205; HU P9801629 A 19960205; PL 32171196 A 19960205