EP 0811016 A1 19971210 - SYNTHETIC PEPTIDE BASED IMMUNOGENS FOR THE TREATMENT OF ALLERGY
Title (en)
SYNTHETIC PEPTIDE BASED IMMUNOGENS FOR THE TREATMENT OF ALLERGY
Title (de)
AUF SYNTHETISCHEN PEPTIDEN BASIERENDE IMMUNOGENE FÜR DIE BEHANDLUNG DER ALLERGIE
Title (fr)
IMMUNOGENES A BASE DE PEPTIDE SYNTHETIQUE POUR LE TRAITEMENT DE L'ALLERGIE
Publication
Application
Priority
- US 21846194 A 19940328
- US 32891294 A 19941025
- US 9503741 W 19950324
Abstract (en)
[origin: WO9526365A1] The present invention relates to a method for eliciting the production in healthy mammals, including humans, of high titer antibodies to an effector site in human IgE heavy chain, i.e. a site in the CH4 domain of the ELEMENT -chain, by the use of compositions of synthetic peptide immunogens in either a radially branching multimeric form (such as branching octameric or hexadecameric peptides) or a linearly arranged monomeric form, to inhibit mast cell activation and reduce allergen-induced IgE production. It also relates to the use of such "optimally" designer, carrier protein free, IgE ELEMENT -chain related immunogens as key components in a synthetic vaccine to provide an immunotherapy for the treatment of allergy. The subject peptides contain immune stimulator sequences, including a built-in helper T cell epitope tandemly linked in a specific orientation, to aid in stimulating the immune response towards the IgE CH4 domain.
IPC 1-7
IPC 8 full level
A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61P 37/08 (2006.01); C07K 16/00 (2006.01); C07K 16/42 (2006.01); C07K 19/00 (2006.01)
CPC (source: EP)
A61K 39/0005 (2013.01); A61P 37/08 (2017.12); C07K 16/00 (2013.01); C07K 16/4291 (2013.01); C07K 19/00 (2013.01); A61K 2039/645 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9526365 A1 19951005; AU 2195395 A 19951017; CA 2186595 A1 19951005; CN 1146772 A 19970402; EP 0811016 A1 19971210; EP 0811016 A4 19971210; JP H09510975 A 19971104
DOCDB simple family (application)
US 9503741 W 19950324; AU 2195395 A 19950324; CA 2186595 A 19950324; CN 95192778 A 19950324; EP 95914876 A 19950324; JP 52523995 A 19950324