EP 0811159 A1 19971210 - A PROCESS FOR IDENTIFIYING PHARMACEUTICALLY ACTIVE AGENTS USING AN EPITOPE-TAGGED LIBRARY
Title (en)
A PROCESS FOR IDENTIFIYING PHARMACEUTICALLY ACTIVE AGENTS USING AN EPITOPE-TAGGED LIBRARY
Title (de)
EIN VERFAHREN ZUR IDENTIFIZIERUNG VON PHARMAZEUTISCHEN WIRKSTOFFEN MIT HILFE EINER EPITOP-MARKIERTEN BANK
Title (fr)
PROCEDE D'IDENTIFICATION D'AGENTS ACTIFS SUR LE PLAN PHARMACOLOGIQUE A L'AIDE D'UNE BANQUE D'EPITOPES MARQUES
Publication
Application
Priority
- US 9602490 W 19960212
- US 38638195 A 19950210
- US 40022095 A 19950307
- US 49735795 A 19950630
Abstract (en)
[origin: WO9624343A1] Invented is a method of treating autoimmune diseases in a subject which comprises administering to the subject a therapeutically effective amount of a compound which binds to a human lck SH2 domain with a binding affinity greater than fifty-fold higher than the binding affinity with which the compound binds to a human src SH2 domain and a human fyn SH2 domain, and, binds to a human hcp SH2 domain, a human Grb2 SH2 domain, a human SH-PTP2 SH2 domain and a human p85 SH2 domain with a binding affinity which is greater than fifty-fold lower than the binding affinity with which the compound binds to such lck SH2 domain.
IPC 1-7
IPC 8 full level
A61K 31/12 (2006.01); C07D 207/50 (2006.01); A61K 31/165 (2006.01); A61K 31/166 (2006.01); A61K 31/195 (2006.01); A61K 31/40 (2006.01); A61K 31/435 (2006.01); A61K 31/437 (2006.01); A61K 31/50 (2006.01); A61K 38/45 (2006.01); A61K 45/00 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); A61P 43/00 (2006.01); C07D 495/14 (2006.01); C07D 495/22 (2006.01); C12P 21/00 (2006.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01); C12R 1/19 (2006.01)
CPC (source: EP KR)
A61K 31/00 (2013.01 - KR); A61K 31/12 (2013.01 - EP); A61K 31/166 (2013.01 - EP); A61K 31/195 (2013.01 - EP); A61K 31/40 (2013.01 - EP); A61K 31/437 (2013.01 - EP); A61K 31/50 (2013.01 - EP); A61P 29/00 (2018.01 - EP); A61P 37/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP)
Designated contracting state (EPC)
BE CH DE DK FR GB IT LI NL
DOCDB simple family (publication)
WO 9624343 A1 19960815; AU 4923796 A 19960827; BR 9607614 A 19980609; CA 2212645 A1 19960815; EP 0809490 A1 19971203; EP 0809490 A4 19991020; EP 0811159 A1 19971210; FI 973259 A0 19970807; FI 973259 A 19971008; HU P9802078 A2 19981228; HU P9802078 A3 19990428; JP H10513474 A 19981222; JP H10513564 A 19981222; KR 19980702115 A 19980715; NO 973659 D0 19970808; NO 973659 L 19971008
DOCDB simple family (application)
US 9601964 W 19960209; AU 4923796 A 19960209; BR 9607614 A 19960209; CA 2212645 A 19960209; EP 96905494 A 19960209; EP 96906615 A 19960212; FI 973259 A 19970807; HU P9802078 A 19960209; JP 52448696 A 19960209; JP 52449396 A 19960212; KR 19970705510 A 19970809; NO 973659 A 19970808