Global Patent Index - EP 0813415 A4

EP 0813415 A4 19980506 - THIONOPHOSPHATE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Title (en)

THIONOPHOSPHATE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Title (de)

THIONOPHOSPHATDERIVATE, VERFAHREN FÜR IHRE HERSTELLUNG UND DIESE ENTHALTENDE PHARMAZEUTISCHE PRÄPARATE

Title (fr)

DERIVES DE THIONOPHOSPHATE, PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

Publication

EP 0813415 A4 19980506 (EN)

Application

EP 95942875 A 19951113

Priority

  • IL 11179794 A 19941128
  • US 9515199 W 19951113

Abstract (en)

[origin: WO9616663A1] The invention relates to a compound of formula (I) in which X1 and X2 each independently represents an oxygen or nitrogen atom; p, m and n are each independently an integer of at least 2; R, R1 and R2 each independently represents a hydrogen atom; a halogen atom; an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; a group R3O in which R3 is hydrogen atom, an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; optionally substituted acyl or optionally substituted aryl or heteroaryl; a group R4O(O)C in which R4 is a hydrogen atom or an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; a group -SR5 in which R5 is a hydrogen atom or an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; a group -NR6R7 in which R6 and R7 each independently represents a hydrogen atom, an optionally substituted straight-chained or branched alkyl, alkenyl or alkynyl radical; optionally substituted acyl; or an optionally substituted phosphate ester group. The invention also relates to processes for the preparation of compounds of the formula and to pharmaceutical compositions containing the same.

IPC 1-7

A61K 31/66; C07F 9/24

IPC 8 full level

A61K 8/55 (2006.01); A61Q 17/00 (2006.01); C07F 9/24 (2006.01)

CPC (source: EP)

A61K 8/55 (2013.01); A61Q 17/00 (2013.01); C07F 9/2458 (2013.01); A61K 2800/522 (2013.01)

Citation (search report)

  • [X] US 3670057 A 19720613 - TSUCHIYA HIROSHI, et al
  • [X] GUO D ET AL: "Phase transfer catalytic synthesis of O,O-diethyl-N-hydrocarbyl phosphoramidothioates", POLYM. MATER. SCI. ENG. (PMSEDG,07430515);93; VOL.69,; PP.482-3, SHANDONG TEACHER'S UNIV.;DEP. OF CHEMISTRY; JINAN; 250014; PEOP. REP. CHINA (CN), XP002055302
  • [X] CHEMICAL ABSTRACTS, vol. 121, no. 9, 29 August 1994, Columbus, Ohio, US; abstract no. 109001, GUO D ET AL: "N-substituted-O,O-diethylphosphoramidothioates" XP002055304 & HECHENG HUAXUE (HEHUE2);94; VOL.2 (2); PP.185-9, SHANDONG NORMAL UNIV.;DEP. CHEM.; JINAN; 250014; PEOP. REP. CHINA (CN)
  • [X] CHEMICAL ABSTRACTS, vol. 071, no. 1, 7 July 1969, Columbus, Ohio, US; abstract no. 003242, KAS'YANOVA E F ET AL: "Synthesis of some derivatives of monothiophosphoric acid for the flotation of ores of heavy nonferrous metals" XP002055305 & ZH. OBSHCH. KHIM. (ZOKHA4);69; VOL.39 (2); PP.365-6, USSR
  • [X] CHEMICAL ABSTRACTS, vol. 092, no. 13, 31 March 1980, Columbus, Ohio, US; abstract no. 110472, KRONGAUZ Y I ET AL: "Reaction of thiophosphoric acid chlorides with ethanolamine" XP002055306 & NOV. KHIM. SREDSTVA ZASHCH. RAST. (42DUA7);79; PP.11-15, USSR
  • [X] CHEMICAL ABSTRACTS, vol. 085, no. 17, 25 October 1976, Columbus, Ohio, US; abstract no. 123267, MANDEL'BAUM Y A ET AL: "Reaction of phosphorus thio acid chlorides with ethanolamine" XP002055307 & ZH. OBSHCH. KHIM. (ZOKHA4);76; VOL.46 (8); PP.1757-8, USSR
  • [A] KELNER M.J.: "Thioureas react with superoxide radicals to yield a sulfhydril compound", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 265, no. 3, 1990, MD US, pages 1306 - 1311, XP002057035
  • [T] TIROSH O ET AL: "Antioxidant properties of amidothionophosphates: novel antioxidant molecules", FREE RADICAL BIOL. MED. (FRBMEH,08915849);96; VOL.20 (3); PP.421-32, HEBREW UNIV. JERUSALEM;DEP. PHARM.; JERUSALEM; ISRAEL (IL), XP002055303
  • See references of WO 9616663A1

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9616663 A1 19960606; AU 4408196 A 19960619; CA 2206374 A1 19960606; EP 0813415 A1 19971229; EP 0813415 A4 19980506; IL 111797 A0 19950124

DOCDB simple family (application)

US 9515199 W 19951113; AU 4408196 A 19951113; CA 2206374 A 19951113; EP 95942875 A 19951113; IL 11179794 A 19941128