EP 0815120 B1 20010214 - 17-DIFLUOROMETHYLENE-OESTRATRIENES
Title (en)
17-DIFLUOROMETHYLENE-OESTRATRIENES
Title (de)
17-DIFLUORMETHYLEN-ESTRATRIENE
Title (fr)
17-DIFLUOROMETHYLENE-OESTRATIENES
Publication
Application
Priority
- DE 19509729 A 19950313
- EP 9601069 W 19960313
Abstract (en)
[origin: DE19509729A1] The invention concerns novel 17-difluoromethylene-oestratrienes of general formula (I), in which: R<1> is a hydrogen atom or a C1-C10 alkyl group; R<5> is a methyl or ethyl group; R<2> is a hydrogen atom or an alpha - or beta -position C1-C10 alkyl group; R<3> is a hydrogen atom or C1-C10 alkyloxy group; R<4> is an alpha - or beta -position hydrogen atom; A, B, C, D, E and G each stand for a hydrogen atom; and optionnaly at least one of the substituent pairs G and R<2>, R<2> and R<4>, R<4> and A, A and R<3>, B and D, D and E represent a double bond. The novel compounds have antioxidant and vasculoprotective properties not previously noted in steroids and are suitable for use in the production of pharmaceutical preparations.
IPC 1-7
IPC 8 full level
A61K 31/02 (2006.01); A61K 31/35 (2006.01); A61K 31/56 (2006.01); A61K 31/352 (2006.01); A61K 31/435 (2006.01); A61K 31/47 (2006.01); A61K 31/505 (2006.01); A61K 31/565 (2006.01); A61K 31/70 (2006.01); A61K 31/7028 (2006.01); A61K 31/7034 (2006.01); A61K 31/7042 (2006.01); A61K 31/7048 (2006.01); A61P 7/00 (2006.01); A61P 9/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 311/10 (2006.01); C07D 401/04 (2006.01); C07D 487/04 (2006.01); C07D 491/14 (2006.01); C07D 493/04 (2006.01); C07D 513/04 (2006.01); C07H 15/203 (2006.01); C07H 15/26 (2006.01); C07H 17/04 (2006.01); C07J 13/00 (2006.01); C07K 5/06 (2006.01); C07K 5/062 (2006.01); C07K 5/068 (2006.01); C07K 5/072 (2006.01); C07K 9/00 (2006.01)
CPC (source: EP KR US)
A61K 31/02 (2013.01 - EP US); A61K 31/56 (2013.01 - KR); A61P 7/00 (2018.01 - EP); A61P 9/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 401/04 (2013.01 - EP US); C07D 487/04 (2013.01 - EP US); C07H 15/203 (2013.01 - EP US); C07J 13/00 (2013.01 - KR); C07J 13/007 (2013.01 - EP US); C07K 9/001 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
DE 19509729 A1 19960919; AT E199159 T1 20010215; AU 5107896 A 19961002; AU 693335 B2 19980625; BR 9612787 A 19991123; CA 2215201 A1 19960919; CZ 281097 A3 19980218; DE 59606435 D1 20010322; EP 0815120 A1 19980107; EP 0815120 B1 20010214; HU P9801846 A2 19981228; HU P9801846 A3 19990301; IL 117497 A0 19960723; IL 117497 A 19991222; IS 4556 A 19970908; JP H11501644 A 19990209; KR 19980703002 A 19980905; MX 9707006 A 19971129; NO 308306 B1 20000828; NO 974206 D0 19970912; NO 974206 L 19971113; PL 322199 A1 19980119; RU 2155770 C2 20000910; SI 9620030 A 19980228; SK 121697 A3 19980204; TR 199700950 T1 19980221; US 6018062 A 20000125; US 6136800 A 20001024; WO 9628462 A1 19960919; ZA 962037 B 19960925
DOCDB simple family (application)
DE 19509729 A 19950313; AT 96907453 T 19960313; AU 5107896 A 19960313; BR 9612787 A 19960313; CA 2215201 A 19960313; CZ 281097 A 19960313; DE 59606435 T 19960313; EP 9601069 W 19960313; EP 96907453 A 19960313; HU P9801846 A 19960313; IL 11749796 A 19960314; IS 4556 A 19970908; JP 52727696 A 19960313; KR 19970706410 A 19970912; MX 9707006 A 19960313; NO 974206 A 19970912; PL 32219996 A 19960313; RU 97116513 A 19960313; SI 9620030 A 19960313; SK 121697 A 19960313; TR 9700950 T 19960313; US 26306299 A 19990308; US 91332598 A 19980223; ZA 962037 A 19960313