EP 0815244 A1 19980107 - THERMITASE VARIANTS HAVING DECREASED ADSORPTION AND INCREASED HYDROLYSIS
Title (en)
THERMITASE VARIANTS HAVING DECREASED ADSORPTION AND INCREASED HYDROLYSIS
Title (de)
THERMITASE VARIANTEN MIT VERMINDERTER ADSORPTION UND ERHÖHTER HYDROLYSE
Title (fr)
VARIANTS DE LA THERMITASE DOTES D'UN POUVOIR D'ADSORPTION REDUIT ET D'UNE CAPACITE D'HYDROLYSE ACCRUE
Publication
Application
Priority
- US 9603009 W 19960306
- US 40157395 A 19950309
Abstract (en)
[origin: WO9628558A1] The present invention relates to Thermitase variants having a modified amino acid sequence of wild-type Thermitase amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region, a fifth loop region and a sixth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type Thermitase (i.e., substitution) at specifically identified positions in one or more of the loop regions whereby the Thermitase variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type Thermitase. The present invention also relates to DNA sequences encoding such Thermitase variants. The present invention also relates to compositions comprising such Thermitase variants for cleaning a variety of surfaces.
IPC 1-7
IPC 8 full level
A61K 8/66 (2006.01); A61Q 11/00 (2006.01); C11D 3/00 (2006.01); C11D 3/386 (2006.01); C11D 7/42 (2006.01); C12N 9/52 (2006.01); C12N 9/56 (2006.01); C12N 15/09 (2006.01); C12N 15/00 (2006.01); C12N 15/57 (2006.01); C12R 1/125 (2006.01)
CPC (source: EP)
A61K 8/66 (2013.01); A61Q 11/00 (2013.01); C11D 3/0078 (2013.01); C11D 3/386 (2013.01); C12N 9/52 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9628558 A1 19960919; AU 5182996 A 19961002; BR 9607756 A 19990330; CA 2214578 A1 19960919; CN 1183118 A 19980527; CZ 280097 A3 19980114; EP 0815244 A1 19980107; HU P9802069 A2 19981228; HU P9802069 A3 20001128; IL 117352 A0 19960723; IN 187236 B 20020309; JP H11501816 A 19990216; MA 23819 A1 19961001; MX 9706846 A 19971129; ZA 961822 B 19960911
DOCDB simple family (application)
US 9603009 W 19960306; AU 5182996 A 19960306; BR 9607756 A 19960306; CA 2214578 A 19960306; CN 96193608 A 19960306; CZ 280097 A 19960306; EP 96908663 A 19960306; HU P9802069 A 19960306; IL 11735296 A 19960304; IN 457DE1996 A 19960306; JP 52769396 A 19960306; MA 24176 A 19960307; MX 9706846 A 19960306; ZA 961822 A 19960306