EP 0815256 A1 19980107 - PROCESS FOR THE PREPARATION OF A BETA-LACTAM ANTIBIOTIC
Title (en)
PROCESS FOR THE PREPARATION OF A BETA-LACTAM ANTIBIOTIC
Title (de)
VERFAHREN ZUR HERSTELLUNG VON EINEM BETA-LACTAM ANTIBIOTIKA
Title (fr)
PROCEDE DE PREPARATION D'UNE BETA-LACTAMINE
Publication
Application
Priority
- BE 9500081 A 19950202
- NL 9600052 W 19960201
Abstract (en)
[origin: WO9623897A1] The invention relates to a process for the preparation of a beta -lactam antibiotic by enzymatic acylation of a beta -lactam core by means of an acylation agent, with the molar ratio between the beta -lactam core and the acylation agent being between 0.5:1 and 2:1, the concentration of inorganic salts in the reaction mixture being lower than 1000:n mM, n representing the valency of the anion, and the sum of the concentrations of the beta -lactam antibiotic and the beta -lactam core being between 200 and 800 mM. This process offers the advantage that the enzyme can be re-used many times without much loss of activity of the enzyme. This makes it possible to obtain a commercially attractive process for the preparation of beta -lactam antibiotics via enzymatic acylation of beta -lactam cores.
IPC 1-7
IPC 8 full level
C07D 501/00 (2006.01); C12P 35/00 (2006.01)
CPC (source: EP)
C07D 501/00 (2013.01); C12P 35/00 (2013.01)
Citation (search report)
See references of WO 9623897A1
Designated contracting state (EPC)
ES IT
DOCDB simple family (publication)
WO 9623897 A1 19960808; AU 4846296 A 19960821; BE 1009071 A3 19961105; EP 0815256 A1 19980107; IN 181940 B 19981114; IN 182469 B 19990417
DOCDB simple family (application)
NL 9600052 W 19960201; AU 4846296 A 19960201; BE 9500081 A 19950202; EP 96904337 A 19960201; IN 161MA1996 A 19960201; IN 162MA1996 A 19960201