EP 0819125 B1 20030618 - THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN
Title (en)
THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN
Title (de)
THIENYL-, FURYL-, PYRROLYL- UND BIPHENYLSULFONAMIDE UND DERIVATE ZUR MODULATION DER ENDOTHELIN-AKTIVITÄT
Title (fr)
THIENYL-, FURYL-, PYRROLYL- ET BIPHENYL SULFONAMIDES ET LEURS DERIVES MODULANT L'ACTIVITE DE L'ENDOTHELINE
Publication
Application
Priority
- US 9604759 W 19960404
- US 41619995 A 19950404
- US 41707595 A 19950404
- US 47722395 A 19950606
Abstract (en)
[origin: WO9631492A1] Thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)-furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.
IPC 1-7
C07D 261/16; C07D 261/14; C07D 413/12; A61K 31/42; C07D 413/14; C07D 417/14
IPC 8 full level
C07D 333/34 (2006.01); A61K 31/38 (2006.01); A61K 31/381 (2006.01); A61K 31/42 (2006.01); A61K 31/422 (2006.01); A61K 31/427 (2006.01); A61K 31/433 (2006.01); A61K 31/4439 (2006.01); A61K 31/496 (2006.01); A61P 1/00 (2006.01); A61P 1/04 (2006.01); A61P 9/00 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01); A61P 13/02 (2006.01); A61P 13/12 (2006.01); A61P 15/00 (2006.01); A61P 15/08 (2006.01); A61P 17/00 (2006.01); A61P 27/02 (2006.01); A61P 27/06 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07D 261/16 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01)
CPC (source: EP KR)
A61K 31/42 (2013.01 - KR); A61P 1/00 (2017.12 - EP); A61P 1/04 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/08 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 13/00 (2017.12 - EP); A61P 13/02 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 15/08 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 27/06 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 261/14 (2013.01 - KR); C07D 261/16 (2013.01 - EP KR); C07D 413/12 (2013.01 - EP KR); C07D 413/14 (2013.01 - EP); C07D 417/12 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9631492 A1 19961010; AT E243203 T1 20030715; AU 5536796 A 19961023; AU 711968 B2 19991028; CA 2217169 A1 19961010; CA 2217169 C 20050329; CN 1130355 C 20031210; CN 1184470 A 19980610; CZ 299246 B6 20080528; CZ 311697 A3 19980916; DE 122006000068 I1 20070510; DE 69628740 D1 20030724; DE 69628740 T2 20040513; DK 0819125 T3 20031013; EA 007107 B1 20060630; EA 199700208 A1 19980827; EA 199900808 A1 20000626; EE 9700251 A 19980415; EP 0819125 A1 19980121; EP 0819125 B1 20030618; EP 1048657 A1 20001102; ES 2201181 T3 20040316; FI 973879 A0 19971003; HK 1001769 A1 19980710; HU P9802034 A2 20000328; HU P9802034 A3 20000428; JP 2002030075 A 20020129; JP 2004043495 A 20040212; JP 3233642 B2 20011126; JP 3527217 B2 20040517; JP H11507015 A 19990622; KR 100359396 B1 20030315; KR 100359397 B1 20021101; KR 19980703679 A 19981205; NL 300251 I1 20070201; NL 300251 I2 20070301; NO 315607 B1 20030929; NO 974577 D0 19971003; NO 974577 L 19971204; NZ 306734 A 20000128; NZ 500282 A 20000128; OA 10621 A 20010316; PL 186854 B1 20040331; PL 322707 A1 19980216; PT 819125 E 20031128; TR 199701096 T1 19980221; TW 492966 B 20020701
DOCDB simple family (application)
US 9604759 W 19960404; AT 96912600 T 19960404; AU 5536796 A 19960404; CA 2217169 A 19960404; CN 96193973 A 19960404; CZ 311697 A 19960404; DE 69628740 C 19960404; DE 69628740 T 19960404; DK 96912600 T 19960404; EA 199700208 A 19960404; EA 199900808 A 19960404; EE 9700251 A 19960404; EP 00113076 A 19960404; EP 96912600 A 19960404; ES 96912600 T 19960404; FI 973879 A 19971003; HK 98100844 A 19980205; HU P9802034 A 19960404; JP 2001171692 A 20010606; JP 2003318261 A 20030910; JP 53052496 A 19960404; KR 19970707078 A 19971004; KR 19997007068 A 19990805; NL 300251 C 20061213; NO 974577 A 19971003; NZ 30673496 A 19960404; NZ 50028296 A 19960404; OA 70095 A 19971002; PL 32270796 A 19960404; PT 96912600 T 19960404; TR 9701096 T 19960404; TW 85112218 A 19961004