EP 0820466 A2 19980128 - FLUORESCENT PEPTIDES
Title (en)
FLUORESCENT PEPTIDES
Title (de)
FLUORESZIERENDE PEPTIDE
Title (fr)
PEPTIDES FLUORESCENT
Publication
Application
Priority
- CA 9600207 W 19960404
- US 41600795 A 19950404
- US 47575195 A 19950607
- US 50485695 A 19950720
Abstract (en)
[origin: WO9631531A2] The invention provides biologically active compounds of formula (I) where R1 is a light-emitting moiety and R7 is a peptide of between 2 and 200 amino acids. X is selected from the group including =O, =S, -OH, =C=O, =NH, -H, -OR, -NR, -R, -R3R4, wherein each R, R4 and R3, independently, is H or a C1-C6 branched or unbranched, substituted or unsubstituted, alkyl. The compounds are both biologically active and optically detectable. The peptide is chemically attached to the light-emitting moiety at an amino acid position which is not involved in binding to the peptide's receptor. In this way, the peptide's affinity for its receptor is not significantly decreased, and the compound retains high biological activity and can be easily detected using standard optical means.
IPC 1-7
IPC 8 full level
C07K 7/06 (2006.01); C07K 7/14 (2006.01); C07K 14/575 (2006.01); G01N 33/50 (2006.01); G01N 33/569 (2006.01)
CPC (source: EP)
C07K 7/06 (2013.01); C07K 7/14 (2013.01); C07K 14/575 (2013.01); C07K 14/57536 (2013.01); C07K 14/57563 (2013.01); G01N 33/5094 (2013.01); G01N 33/56966 (2013.01)
Citation (search report)
See references of WO 9631531A2
Designated contracting state (EPC)
BE CH DE DK FI FR GB IE IT LI NL SE
DOCDB simple family (publication)
WO 9631531 A2 19961010; WO 9631531 A3 19970220; EP 0820466 A2 19980128
DOCDB simple family (application)
CA 9600207 W 19960404; EP 96908950 A 19960404