EP 0821589 B1 20090204 - COMPOSITIONS AND METHODS TO PREVENT TOXICITY INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS
Title (en)
COMPOSITIONS AND METHODS TO PREVENT TOXICITY INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS
Title (de)
MITTEL UND VERFAHREN ZUR VERHINDERUNG DER DURCH NICHTSTEROIDALE ANTIINFLAMMATORISCHE ARZNEISTOFFE VERURSACHTEN TOXIZITÄT
Title (fr)
COMPOSITIONS ET PROCEDES PERMETTANT D'EMPECHER LA TOXICITE INDUITE PAR LES MEDICAMENTS ANTI-INFLAMMATOIRES NON STEROIDIENS
Publication
Application
Priority
- US 9604931 W 19960411
- US 42509095 A 19950419
- US 54320895 A 19951013
Abstract (en)
[origin: WO9632946A1] Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising: (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/19 (2006.01); A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 31/405 (2006.01); A61K 31/54 (2006.01); A61K 31/541 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61P 1/00 (2006.01); A61P 1/04 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07C 203/00 (2006.01); C07C 327/28 (2006.01); C07C 381/00 (2006.01); C07D 209/28 (2006.01); C07D 417/04 (2006.01); C07D 417/12 (2006.01); C07D 513/00 (2006.01); C07D 513/02 (2006.01); C07D 513/04 (2006.01); C07J 41/00 (2006.01); C07K 5/02 (2006.01)
CPC (source: EP US)
A61K 31/343 (2013.01 - EP US); A61K 31/60 (2013.01 - EP US); A61P 1/00 (2017.12 - EP); A61P 1/04 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07C 203/00 (2013.01 - EP US); C07C 327/28 (2013.01 - EP US); C07C 381/00 (2013.01 - EP US); C07D 209/28 (2013.01 - EP US); C07D 417/12 (2013.01 - EP US); C07J 41/0055 (2013.01 - EP US); C07K 5/0215 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Designated contracting state (EPC)
CH DE FR GB IT LI SE
DOCDB simple family (publication)
WO 9632946 A1 19961024; AU 5449396 A 19961107; AU 710951 B2 19990930; CA 2218555 A1 19961024; CA 2218555 C 20030923; EP 0821589 A1 19980204; EP 0821589 A4 20020515; EP 0821589 B1 20090204; JP 2007291127 A 20071108; JP H11509519 A 19990824; US 2003109520 A1 20030612; US 2005038029 A1 20050217; US 2006276439 A1 20061207; US 2008275010 A1 20081106; US 5703073 A 19971230; US 6043233 A 20000328; US 6048858 A 20000411; US 6057347 A 20000502; US 6083515 A 20000704; US 6323234 B1 20011127; US 6482846 B1 20021119; US 6790864 B2 20040914
DOCDB simple family (application)
US 9604931 W 19960411; AU 5449396 A 19960411; CA 2218555 A 19960411; EP 96911685 A 19960411; JP 2007167646 A 20070626; JP 53179796 A 19960411; US 17451008 A 20080716; US 23580199 A 19990122; US 23580399 A 19990122; US 23580499 A 19990122; US 27720202 A 20021022; US 50590506 A 20060818; US 51854100 A 20000303; US 54320895 A 19951013; US 93090104 A 20040901; US 93156497 A 19970916; US 94169001 A 20010830