EP 0821591 A1 19980204 - CNS NEURITE OUTGROWTH MODULATORS, AND COMPOSITIONS, CELLS AND METHODS EMBODYING AND USING SAME
Title (en)
CNS NEURITE OUTGROWTH MODULATORS, AND COMPOSITIONS, CELLS AND METHODS EMBODYING AND USING SAME
Title (de)
MODULATOREN DES WACHSTUMS VON NEURITEN DES ZENTRALNERVENSYSTEMS, ZUSAMMENSETZUNGEN, ZELLEN UND VERFAHREN, DIE DIESE BEINTHALTEN
Title (fr)
MODULATEURS DE LA CROISSANCE DE L'AXONE ET DES DENDRITES DU SYSTEME NERVEUX CENTRAL, COMPOSITIONS, CELLULES ET PROCEDES DANS LESQUELS ILS SONT MIS EN UVRE ET UTILISES
Publication
Application
Priority
- US 9605434 W 19960419
- US 42499595 A 19950419
- US 48395995 A 19950607
Abstract (en)
[origin: WO9632959A1] The invention features a method for promoting neural growth in vivo in the mammalian central nervous system by administering a neural cell adhesion molecule which can overcome inhibitory molecular cues found on glial cells and myelin to promote neural growth. Also featured active fragments, cognates, congeners, mimics, analogs, secreting cells and soluble molecules thereof, as well as antibodies thereto, and DNA molecules, vectors and transformed cells capable of expressing them. The invention also includes transgenic mouse lines expressing a neural adhesion molecule in differentiated astrocytes, and cells and tissues derived therefrom. The expression of the neural adhesion molecule enhances neurite outgrowth on central nervous system tissue derived from these transgenic mice. The invention also features methods for enhancing neuronal outgrowth of CNS neurons, for enhancing memory and for increasing synaptic efficacy. Also featured are methods of testing drugs which modulate the effects of the neural adhesion molecule, and assay systems suitable for such methods.
IPC 1-7
A61K 38/17; A61K 39/395; A61K 38/39; C12N 15/12; C12N 5/10; C07K 16/28; A01K 67/027; G01N 33/50; G01N 33/68
IPC 8 full level
A61K 35/74 (2006.01); A61K 38/00 (2006.01); A61K 38/16 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 25/00 (2006.01); A61P 43/00 (2006.01); C07K 14/705 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); A01K 67/027 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP KR)
A01K 67/0275 (2013.01 - EP); A61K 38/17 (2013.01 - KR); A61K 38/39 (2013.01 - KR); A61P 25/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 14/70503 (2013.01 - EP); C07K 16/2803 (2013.01 - EP); G01N 33/5058 (2013.01 - EP); A01K 2217/05 (2013.01 - EP); A01K 2227/105 (2013.01 - EP); A01K 2267/03 (2013.01 - EP); A61K 38/00 (2013.01 - EP); A61K 48/00 (2013.01 - EP); A61K 2039/505 (2013.01 - EP); C07K 2317/34 (2013.01 - EP); C12N 2830/008 (2013.01 - EP); G01N 2333/70503 (2013.01 - EP); G01N 2333/78 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9632959 A1 19961024; AU 5557296 A 19961107; AU 718508 B2 20000413; CA 2218599 A1 19961024; CZ 330197 A3 19980415; EA 199700323 A1 19980430; EP 0821591 A1 19980204; HU P9900060 A2 19990428; HU P9900060 A3 20010828; IS 4590 A 19971015; JP H11504211 A 19990420; KR 19990007893 A 19990125; MX 9708127 A 19980628; NO 974811 D0 19971017; NO 974811 L 19971219; PL 322947 A1 19980302; SK 142497 A3 19990806; TR 199701203 T1 19980321; TR 199801650 T2 19990322
DOCDB simple family (application)
US 9605434 W 19960419; AU 5557296 A 19960419; CA 2218599 A 19960419; CZ 330197 A 19960419; EA 199700323 A 19960419; EP 96912910 A 19960419; HU P9900060 A 19960419; IS 4590 A 19971015; JP 53193296 A 19960419; KR 19970707416 A 19971020; MX 9708127 A 19971020; NO 974811 A 19971017; PL 32294796 A 19960419; SK 142497 A 19960419; TR 9701203 T 19960419; TR 9801650 T 19960419