EP 0821694 A1 19980204 - CONOTOXIN PEPTIDES
Title (en)
CONOTOXIN PEPTIDES
Title (de)
CONOTOXIN-PEPTIDE
Title (fr)
PEPTIDES DE CONOTOXINE
Publication
Application
Priority
- US 9605262 W 19960417
- US 42356195 A 19950417
- US 59955696 A 19960215
- US 62412396 A 19960329
Abstract (en)
[origin: WO9633206A1] The present invention is directed to conotoxin peptides, specifically delta -conotoxin PVIA and mu -conotoxin PIIIA. delta -conotoxin PVIA is found in the Eastern Pacific fish hunting species of cone snails Conus purpurascens. It consists of 29 amino acid residues of the sequence: Glu-Ala-Cys-Tyr-Ala-Xaa1-Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa2-Gly-Leu-Cys-Cys-Ser-Glu-Phe-Cys-Leu-Pro-Gly-Val-Cys-Pro-Gly (SEQ ID NO:1) where Xaa1 or Xaa2 is Pro or 4-trans-hydroxyproline. The C-terminus may be free or amidated. delta -conotoxin PVIA is vertebrate specific and targets voltage-sensitive Na<+> channels. mu -conotoxin PIIIA is also found in Conus purpurascens. It consists of 22 amino acid residues of the sequence: Xaa1-Arg-Leu-Cys-Cys-Gly-Phe-Xaa2-Lys-Ser-Cys-Arg-Ser-Arg-Gln-Cys-Lys-Xaa2-His-Arg-Cys-Cys (SEQ ID NO:2) where Xaa1 represents pyroglutamate or glutamine and Xaa2 represents 4-trans-hydroxyproline or proline. This latter peptide targets sodium channels.
[origin: WO9633206A1] The present invention is directed to conotoxin peptides, specifically delta -conotoxin PVIA and mu -conotoxin PIIIA. delta -conotoxin PVIA is found in the Eastern Pacific fish hunting species of cone snails Conus purpurascens. It consists of 29 amino acid residues of the sequence: Glu-Ala-Cys-Tyr-Ala-Xaa1-Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa2-Gly-Leu-Cys- Cys-Ser-Glu-Phe-Cys-Leu-Pro-Gly-Val-Cys-Pro-Gly (SEQ ID NO:1) where Xaa1 or Xaa2 is Pro or 4-trans-hydroxyproline. The C-terminus may be free or amidated. delta -conotoxin PVIA is vertebrate specific and targets voltage-sensitive Na<+> channels. mu -conotoxin PIIIA is also found in Conus purpurascens. It consists of 22 amino acid residues of the sequence: Xaa1-Arg-Leu-Cys-Cys-Gly-Phe-Xaa2-Lys-Ser-Cys-Arg-Ser-Arg-Gln-Cys-Lys- Xaa2-His-Arg-Cys-Cys (SEQ ID NO:2) where Xaa1 represents pyroglutamate or glutamine and Xaa2 represents 4-trans-hydroxyproline or proline. This latter peptide targets sodium channels.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); C07K 14/435 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/435 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9633206 A1 19961024; AU 5550296 A 19961107; AU 700592 B2 19990107; CA 2216751 A1 19961024; EP 0821694 A1 19980204; EP 0821694 A4 19990414; JP H11503909 A 19990406
DOCDB simple family (application)
US 9605262 W 19960417; AU 5550296 A 19960417; CA 2216751 A 19960417; EP 96912813 A 19960417; JP 53185596 A 19960417