EP 0823911 A1 19980218 - ESTERS OF CARBAPENEMS
Title (en)
ESTERS OF CARBAPENEMS
Title (de)
CARBAPENEMESTER
Title (fr)
ESTERS DE CARBAPENEMES
Publication
Application
Priority
- EP 9601882 W 19960502
- GB 9508959 A 19950503
- GB 9508964 A 19950503
- GB 9508960 A 19950503
Abstract (en)
[origin: WO9634869A1] A compound of general formula (I) in which R is (a); wherein R< alpha > is hydrogen, optionally substituted (C1-6)alkyl or optionally substituted aryl; R< beta > is hydrogen, optionally substituted (C1-6)alkyl or optionally substituted aryl; or R< alpha > and R< beta > together form an optionally substituted 5 or 6 membered heterocyclic ring with or without additional heteroatoms; R<1> is (C1-6)alkyl which is unsubstituted or substituted by fluoro, a hydroxy group which is optionally protected by a readily removable hydroxy protecting group, or by an amino group which is optionally protected by a readily removable amino protecting group; R<2> is hydrogen or methyl; and R<3> is selected from the group consisting of (a) a group of formula (i) wherein R1 is hydrogen or (C1-6)alkyl, R2 is hydrogen, (C1-6)alkyl optionally substituted by halogen, (C1-6)alkenyl, (C1-6)alkoxycarbonyl, aryl, or heteroaryl, R3 is hydrogen, (C1-6)alkyl, or (C1-6)alkoxycarbonyl, and R4 is a pharmaceutically acceptable ester forming group, and (b) a group of formula CH(R<a>)O.CO.R<b>, wherein R<a> is hydrogen, (C1-6)alkyl, (C3-7)cycloalkyl, methyl, or phenyl; and R<b> is (C1-6)alkyl(C3-7)cycloalkyloxy or (C1-6)alkoxy(C1-6)alkyl, is useful in the treatment of bacterial infections.
IPC 1-7
IPC 8 full level
C07D 477/00 (2006.01); A61K 31/397 (2006.01); A61K 31/415 (2006.01); A61P 31/04 (2006.01); C07D 477/08 (2006.01); C07D 477/14 (2006.01)
CPC (source: EP KR)
A61K 31/415 (2013.01 - KR); A61P 31/04 (2017.12 - EP); C07D 477/08 (2013.01 - EP KR); C07D 477/14 (2013.01 - EP KR); Y02P 20/55 (2015.11 - EP)
Citation (search report)
See references of WO 9634869A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9634869 A1 19961107; AU 5814196 A 19961121; BR 9608318 A 19990126; CA 2217885 A1 19961107; CN 1184480 A 19980610; CZ 347697 A3 19980617; EP 0823911 A1 19980218; HU P9801061 A2 19980828; HU P9801061 A3 19990128; JP H11504912 A 19990511; KR 19990008354 A 19990125; MX 9708422 A 19980228; NO 974995 D0 19971030; NO 974995 L 19971030; PL 323148 A1 19980316; TR 199701289 T2 19980821
DOCDB simple family (application)
EP 9601882 W 19960502; AU 5814196 A 19960502; BR 9608318 A 19960502; CA 2217885 A 19960502; CN 96194015 A 19960502; CZ 347697 A 19960502; EP 96919680 A 19960502; HU P9801061 A 19960502; JP 53302296 A 19960502; KR 19970707880 A 19971103; MX 9708422 A 19960502; NO 974995 A 19971030; PL 32314896 A 19960502; TR 9701289 T 19960502