EP 0825811 A1 19980304 - NON-GENETICALLY MODIFIED MAMMAL AS A MODEL FOR MULTIPLE SCLEROSIS
Title (en)
NON-GENETICALLY MODIFIED MAMMAL AS A MODEL FOR MULTIPLE SCLEROSIS
Title (de)
NICHT-GENETISCH MODIFIZIERTES TIER ALS MODELL FUER MULTIPLE SKLEROSE
Title (fr)
MAMMIFERE NON GENETIQUEMENT MODIFIE, MODELE POUR LA SCLEROSE EN PLAQUES
Publication
Application
Priority
- FR 9700469 W 19970314
- FR 9603417 A 19960314
Abstract (en)
[origin: WO9733466A1] A non-human mammal genetically modified without affecting its genome and having any two of the following pathological signs: (a) a blood-brain barrier that is open or permeable to water-soluble blood molecules non-specific for the cerebral parenchyma, (b) an astrocyte disorder revealed particularly by physical network disorganisation, the disappearance of perivascular feet around the capillaries, and gliosis, (c) microglial cell activation, (d) demyelinisation plates, particularly in the brain stem and/or the cerebral white matter, and (e) central nervous system glial and endothelial cell lesions, as well as the uses of said animal, are disclosed.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 15/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/00 (2006.01)
CPC (source: EP)
A01K 67/027 (2013.01); C07K 14/4713 (2013.01)
Citation (search report)
See references of WO 9733466A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9733466 A1 19970918; AU 2165897 A 19971001; CA 2221028 A1 19970918; EP 0825811 A1 19980304; FR 2745974 A1 19970919; FR 2745974 B1 19980417; JP H11512623 A 19991102
DOCDB simple family (application)
FR 9700469 W 19970314; AU 2165897 A 19970314; CA 2221028 A 19970314; EP 97914408 A 19970314; FR 9603417 A 19960314; JP 53234397 A 19970314