EP 0826045 A1 19980304 - NUCLEIC ACIDS FOR TREATING OBESITY
Title (en)
NUCLEIC ACIDS FOR TREATING OBESITY
Title (de)
NUKLEINSÄUREN ZUR BEHANDLUNG VON FELTSUCHT
Title (fr)
ACIDES NUCLEIQUES POUR TRAITER L'OBESITE
Publication
Application
Priority
- US 9606609 W 19960508
- US 43783495 A 19950508
Abstract (en)
[origin: WO9635787A1] A nucleic acid molecule is provided that can be expressed in a host cell to produce a biologically active ob polypeptide that can effectively inhibit food intake and/or weight gain. Vectors and host cells containing the nucleic acid molecule are also provided, as well as methods for producing the ob protein and other ob polypeptides, methods of induction of the production of the ob polypeptides, such as by in vivo or ex vivo gene therapy, and methods for inhibition of food intake and/or weight gain. Further provided are antibodies to the ob polypeptides and methods of using such antibodies, such as for identification or detection of other ob polypeptides or homologs thereof, and for inhibition of ob polypeptide activity. A method for identification, detection, or isolation of an ob receptor is provided as well as methods for production of antibodies to the ob receptor. The antibodies and polypeptides herein can be incorporated in kits for immunoassays. Pharmaceutical compositions containing the ob polypeptide and antibodies to the ob polypeptide or to the ob receptor can be used for administration to animals and humans.
IPC 1-7
C12N 15/12; C12N 15/85; C12N 5/10; C12P 21/02; A61K 48/00; C07K 14/575; C07K 14/72; C07K 16/26; G01N 33/53
IPC 8 full level
G01N 33/53 (2006.01); A61K 31/7088 (2006.01); A61K 35/26 (2015.01); A61K 35/76 (2015.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 3/04 (2006.01); C07K 14/435 (2006.01); C07K 14/47 (2006.01); C07K 14/575 (2006.01); C07K 14/72 (2006.01); C07K 16/18 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12R 1/19 (2006.01); C12R 1/645 (2006.01)
CPC (source: EP)
A61P 3/04 (2018.01); C07K 14/43563 (2013.01); C07K 14/5759 (2013.01); C07K 14/72 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C12N 2799/026 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9635787 A1 19961114; AU 5737696 A 19961129; CA 2218529 A1 19961114; EP 0826045 A1 19980304; JP 2000507081 A 20000613
DOCDB simple family (application)
US 9606609 W 19960508; AU 5737696 A 19960508; CA 2218529 A 19960508; EP 96915649 A 19960508; JP 53425796 A 19960508