EP 0828737 A1 19980318 - ISOXAZOLINE AND ISOXAZOLE DERIVATIVES AS INTEGRIN RECEPTOR ANTAGONISTS
Title (en)
ISOXAZOLINE AND ISOXAZOLE DERIVATIVES AS INTEGRIN RECEPTOR ANTAGONISTS
Title (de)
ISOXAZOLIN UND ISOXAZOLE-DERIVATE ALS INTEGRIN-REZEPTOR ANTAGONIST
Title (fr)
DERIVES D'ISOXAZOLINE ET D'ISOXADOLE UTILISES COMME ANTAGONISTES DES RECEPTEURS DE L'INTEGRINE
Publication
Application
Priority
- US 9607646 W 19960524
- US 45064695 A 19950525
- US 45576895 A 19950531
- US 64713296 A 19960509
Abstract (en)
[origin: WO9637492A1] This invention relates to novel heterocycle compounds including but not limited to 3-[3-[3-(imidazolin-2-yl amino)propyloxy]isoxazol-5-ylcarbonylamino]-2-(benzyloxycarbonylamino)-propionic acid, which are useful as antagonists of the alpha v beta 3 and related integrin receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion and the treatment of angiogenic disorders, inflammation, bone degradation, tumors, metastases, thrombosis, and other cell aggregation-related conditions.
IPC 1-7
C07D 413/12; A61K 31/505; A61K 31/42; C07D 413/06; C07D 417/06; C07D 471/04; C07D 413/14; A61K 31/44
IPC 8 full level
A61K 31/42 (2006.01); A61K 31/44 (2006.01); A61K 31/505 (2006.01); A61P 7/02 (2006.01); A61P 9/14 (2006.01); A61P 43/00 (2006.01); C07D 413/06 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/06 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP)
A61P 7/02 (2017.12); A61P 9/14 (2017.12); A61P 43/00 (2017.12); C07D 413/06 (2013.01); C07D 413/12 (2013.01); C07D 417/06 (2013.01)
Citation (search report)
See references of WO 9637492A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9637492 A1 19961128; AU 5876296 A 19961211; CA 2221980 A1 19961128; EP 0828737 A1 19980318; IL 118325 A0 19961031; JP H11506436 A 19990608; MX 9708840 A 19980331
DOCDB simple family (application)
US 9607646 W 19960524; AU 5876296 A 19960524; CA 2221980 A 19960524; EP 96920476 A 19960524; IL 11832596 A 19960520; JP 53589996 A 19960524; MX 9708840 A 19960524