EP 0830455 A1 19980325 - POSITION-SPECIFIC INTEGRATION OF VECTOR CONSTRUCTS INTO EUKARYOTIC GENOMES MEDIATED BY A CHIMERIC INTEGRASE PROTEIN

Title (en)

POSITION-SPECIFIC INTEGRATION OF VECTOR CONSTRUCTS INTO EUKARYOTIC GENOMES MEDIATED BY A CHIMERIC INTEGRASE PROTEIN

Title (de)

POSITIONSSPEZIFISCHE INTEGRATION VON VEKTORKONSTRUKTEN INS EUCARYOTISCHE GENOM DURCH EIN CHIMÄRES INTEGRASE-PROTEIN

Title (fr)

INTEGRATION DE VECTEURS DE RECOMBINAISON DANS UNE POSITION SPECIFIQUE DU GENOME D'UN EUCARYOTE, ASSUREE PAR UNE PROTEINE CHIMERE DU TYPE INTEGRASE

Publication

EP 0830455 A1 19980325 (EN)

Application

EP 96915714 A 19960510

Priority

US 9606727 W 19960510
US 44546695 A 19950522

Abstract (en)

[origin: WO9637626A1] Compositions and methods are provided for directing the position-specific integration of a vector construct encoding one or more desired genes into a specific region of a target eukaryotic genome. Such compositions and methods are useful for performing somatic and germ cell gene therapy. Among the benefits provided by position-specific integration are more uniform levels of expression of a desired gene(s) and substantial elimination of the potential for insertional mutagenesis.

IPC 1-7

C12N 15/90; C12N 15/86; C12N 15/31; C12N 15/48; C12N 15/62; C12N 7/01; C12N 9/22; A61K 31/70; A61K 39/21; A61K 48/00

IPC 8 full level

C12N 15/09 (2006.01); A61K 31/70 (2006.01); A61K 38/43 (2006.01); A61K 39/21 (2006.01); A61K 48/00 (2006.01); A61P 9/00 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 9/22 (2006.01); C12N 15/31 (2006.01); C12N 15/867 (2006.01); C12N 15/90 (2006.01)

CPC (source: EP)

A61P 9/00 (2017.12); A61P 29/00 (2017.12); A61P 35/00 (2017.12); A61P 37/00 (2017.12); C12N 9/22 (2013.01); C12N 15/86 (2013.01); C12N 15/90 (2013.01); A61K 48/00 (2013.01); C07K 2319/00 (2013.01); C12N 2740/13043 (2013.01); C12N 2830/00 (2013.01); C12N 2830/60 (2013.01); C12N 2840/44 (2013.01)

Citation (search report)

See references of WO 9637626A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9637626 A1 19961128; AU 5741996 A 19961211; EP 0830455 A1 19980325; JP H11505128 A 19990518

DOCDB simple family (application)

US 9606727 W 19960510; AU 5741996 A 19960510; EP 96915714 A 19960510; JP 53572096 A 19960510