EP 0830457 A1 19980325 - METHODS FOR EVALUATION OF ANTIMICROBIAL TARGETS
Title (en)
METHODS FOR EVALUATION OF ANTIMICROBIAL TARGETS
Title (de)
VERFAHREN ZUR AUFFINDUNG VON ANTIMIKROBIELLEN ZIELEN
Title (fr)
PROCEDES D'EVALUATION DE CIBLES ANTIMICROBIENNES
Publication
Application
Priority
- US 9607937 W 19960528
- US 48211895 A 19950607
Abstract (en)
[origin: WO9640979A1] Methods for evaluating microbial genes as targets for compounds which inhibit growth of a microbe or alter the pathogenesis of a microbe, and for evaluating the expected therapeutic effect of compounds which inhibit a reaction of a microbial cell which is related to the expression of a specific gene. The methods utilize recombinant microbes which contain DNA construct or alterations, such that the level of activity of the products of coding regions associated with those constructs of alterations can be controlled by contacting the microbe with a specific small molecule or other specific artificial environmental change. Such recombinant microbes can be used in infection models to evaluate the effect of artificially changing the level of activity of a product of a gene.
IPC 1-7
IPC 8 full level
C07K 14/31 (2006.01); C12N 15/70 (2006.01); C12N 15/74 (2006.01); C12Q 1/02 (2006.01)
CPC (source: EP)
C07K 14/31 (2013.01); C12N 15/70 (2013.01); C12N 15/74 (2013.01); C12Q 1/02 (2013.01)
Citation (search report)
See references of WO 9640979A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9640979 A1 19961219; AU 5939996 A 19961230; CA 2223519 A1 19961219; EP 0830457 A1 19980325
DOCDB simple family (application)
US 9607937 W 19960528; AU 5939996 A 19960528; CA 2223519 A 19960528; EP 96916736 A 19960528