EP 0831793 A4 20001115 - PROTEIN PARTICLES FOR THERAPEUTIC AND DIAGNOSTIC USE

Title (en)

PROTEIN PARTICLES FOR THERAPEUTIC AND DIAGNOSTIC USE

Title (de)

PROTEINPARTIKEL ZUR THERAPEUTISCHEN UND DIAGNOSTISCHEN VERWENDUNG

Title (fr)

PARTICULES PROTEIQUES A USAGE THERAPEUTIQUE ET DIAGNOSTIQUE

Publication

EP 0831793 A4 20001115 (EN)

Application

EP 96918313 A 19960604

Priority

US 9609458 W 19960604
US 47165095 A 19950606
US 55491995 A 19951109

Abstract (en)

[origin: WO9639128A1] Albumin particles in the nanometer and micrometer size range in an aqueous suspension are rendered stable against resolubilization without the aid of a cross-linking agent and without denaturation, by the incorporation of a stabilizing agent in the particle composition. Stabilizing agents disclosed include reducing agents, oxidizing agents, hydrogen-accepting molecules, high molecular weight polymers, and sulfur-containing ring compounds. Also disclosed are fibrinogen-coated particles, cross-linked or non-cross-linked, and their use as co-aggregants with platelets and with themselves for purposes of shortening bleeding time and enhancing the effect of thrombin.

IPC 1-7

A61K 9/64; A61K 31/74; A61K 38/38; B01J 13/02; A61K 9/16; A61K 38/36; A61K 9/51

IPC 8 full level

C07D 339/04 (2006.01); A61K 9/107 (2006.01); A61K 9/16 (2006.01); A61K 9/51 (2006.01); A61K 31/70 (2006.01); A61K 35/16 (2015.01); A61K 35/19 (2015.01); A61K 38/00 (2006.01); A61K 47/48 (2006.01); A61P 7/04 (2006.01); B01J 13/00 (2006.01)

CPC (source: EP)

A61K 9/1611 (2013.01); A61K 9/1617 (2013.01); A61K 9/1658 (2013.01); A61K 9/5169 (2013.01); A61K 47/6927 (2017.07); A61P 7/04 (2017.12); B82Y 5/00 (2013.01)

Citation (search report)

[X] US 4925677 A 19900515 - FEIJEN JAN [NL]
[XD] US 4107288 A 19780815 - OPPENHEIM RICHARD CHARLES, et al
[X] US 4147767 A 19790403 - YAPEL JR ANTHONY F
See references of WO 9639128A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9639128 A1 19961212; AU 6100296 A 19961224; CA 2220895 A1 19961212; EP 0831793 A1 19980401; EP 0831793 A4 20001115; JP H11507630 A 19990706

DOCDB simple family (application)

US 9609458 W 19960604; AU 6100296 A 19960604; CA 2220895 A 19960604; EP 96918313 A 19960604; JP 50177296 A 19960604