EP 0831796 A1 19980401 - METHOD FOR REDUCING OR PREVENTING POST-SURGICAL ADHESION FORMATION USING 5-LIPOXYGENASE INHIBITORS

Title (en)

METHOD FOR REDUCING OR PREVENTING POST-SURGICAL ADHESION FORMATION USING 5-LIPOXYGENASE INHIBITORS

Title (de)

VERWENDUNG VON 5-LIPOXYGENASEHEMMER ZUR VOTBEUGUNG ODER VERHINDERUNG POSTCHIRURGISCHER VERKLEBUNG

Title (fr)

PROCEDE POUR LA REDUCTION OU LA PREVENTION DE LA FORMATION D'ADHERENCES POST-CHIRURGICALES A L'AIDE D'INHIBITEURS DE 5-LIPOXYDASE

Publication

EP 0831796 A1 19980401 (EN)

Application

EP 96920600 A 19960531

Priority

US 9608216 W 19960531
US 47318395 A 19950607

Abstract (en)

[origin: WO9640090A1] Compositions and methods for minimizing or preventing post-surgical adhesion formation between tissues, e.g., organ, surfaces in body cavities, whereby an effective therapeutic amount of at least one 5-lipoxygenase inhibitor, e.g., phenidone, NDGA, ETYA and Zileuton, is administered to the target injury site for a period of time sufficient to permit tissue repair. The 5-lipoxygenase inhibitor is preferably administered in conjunction with a delivery vehicle (e.g., microcapsules, microspheres, biodegradable polymer films, lipid-based delivery systems such as liposomes and lipid foams, crystalloid or viscous instillates and absorbable mechanical barriers) useful for maintaining local concentrations of the inhibitor at the injury site at an effective level for a sustained period of time.

IPC 1-7

A61K 31/00; A61K 31/415; A61K 31/05; A61K 31/557; A61K 31/38

IPC 8 full level

A61K 9/50 (2006.01); A61K 31/00 (2006.01); A61K 31/05 (2006.01); A61K 31/20 (2006.01); A61K 31/381 (2006.01); A61K 31/415 (2006.01); A61K 31/4152 (2006.01); A61K 31/557 (2006.01); A61K 45/00 (2006.01); A61K 47/30 (2006.01); A61P 43/00 (2006.01)

CPC (source: EP)

A61K 31/00 (2013.01); A61K 31/05 (2013.01); A61K 31/381 (2013.01); A61K 31/4152 (2013.01); A61K 31/557 (2013.01); A61P 43/00 (2017.12)

Citation (search report)

See references of WO 9640090A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9640090 A1 19961219; AU 5885796 A 19961230; AU 698619 B2 19981105; CA 2223590 A1 19961219; EP 0831796 A1 19980401; JP H11507038 A 19990622

DOCDB simple family (application)

US 9608216 W 19960531; AU 5885796 A 19960531; CA 2223590 A 19960531; EP 96920600 A 19960531; JP 50091597 A 19960531