EP 0831806 A1 19980401 - MULTIDENTATE METAL COMPLEXES AND METHODS OF MAKING AND USING THEREOF
Title (en)
MULTIDENTATE METAL COMPLEXES AND METHODS OF MAKING AND USING THEREOF
Title (de)
MEHRZÄHNIGE METALLKOMPLEXE UND VERFAHREN ZU DEREN HERSTELLUNG UND VERWENDUNG
Title (fr)
COMPLEXES METALLIQUES POLYDENTES ET LEURS PROCEDES DE PREPARATION ET D'UTILISATION
Publication
Application
Priority
- US 9610079 W 19960607
- US 48799195 A 19950607
Abstract (en)
[origin: WO9640108A1] The invention relates to multidentate metal complexes having formula (I) wherein M is Fe, In, Ga or Al; the dashed lines represent independently a sigle or a double bond; the hatched lines represent coordination to the metal cation (M); A and B are oxygen, or in the case where Ar is 2-pyridyl or 2-pyrrolyl, a shared pair of electrons on the nitrogen; Ar is optionally substituted phenyl, optionally substituted naphthyl, optionally substituted 2-pyridyl or optionally substituted 2-pyrrolyl, with the proviso that at least one of the substituents comprises a boron atom; X is alternatively (i) (CHR<2>)p[NR<3>(CHR<4>)q]r, wherein p and q are independently 1, 2, 3, 4, 5 or 6; r is 0, 1 or 2; and R<2>, R<3> and R<4> are independently hydrogen, lower alkyl or phenyl, or two adjacent R<2> or R<4> groups represent a double bond or a fused benzene ring where p or q, respectively, is greater than 2; with the proviso that where r is 1 or 2, then there are 1 or two additional sites of coordination to the metal; or (ii) optionally substituted phenyl, wherein the phenyl, when substituted, has lower alkyl substituents, optionally with: proviso (A), wherein at least one of the substituents of Ar comprises boron, or with proviso (B), wherein at least one of substituents of Ar comprises a linkage to a pharmaceutically active substituent.
IPC 1-7
A61K 31/33; A61K 31/555; C07F 5/00; C07F 5/06; C07F 7/10; C07F 15/02
IPC 8 full level
A61K 41/00 (2006.01); A61K 31/28 (2006.01); A61K 31/285 (2006.01); A61K 31/555 (2006.01); A61K 31/70 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61P 33/02 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 273/00 (2006.01); C07F 5/00 (2006.01); C07F 5/06 (2006.01); C07F 15/02 (2006.01)
CPC (source: EP)
A61K 31/555 (2013.01); A61P 33/02 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 273/00 (2013.01); Y02A 50/30 (2017.12)
Citation (search report)
See references of WO 9640108A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9640108 A1 19961219; AU 6477196 A 19961230; CA 2224115 A1 19961219; EP 0831806 A1 19980401; JP H11507641 A 19990706; MX 9709471 A 19980228
DOCDB simple family (application)
US 9610079 W 19960607; AU 6477196 A 19960607; CA 2224115 A 19960607; EP 96924270 A 19960607; JP 50218897 A 19960607; MX 9709471 A 19960607