Global Patent Index - EP 0831816 A1

EP 0831816 A1 19980401 - USE OF BENZIMIDAZOLES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF LEUKEMIA

Title (en)

USE OF BENZIMIDAZOLES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF LEUKEMIA

Title (de)

VERWENDUNG VON BENZIMIDAZOLEN ZUR HERSTELLUNG EINES ARZNEIMITTELS ZUR BEHANDLUNG VON LEUKÄMIE

Title (fr)

UTILISATION DE BENZIMIDAZOLES DANS LA FABRICATION D'UN MEDICAMENT DESTINE AU TRAITEMENT DE LA LEUCEMIE

Publication

EP 0831816 A1 19980401 (EN)

Application

EP 96914749 A 19960522

Priority

  • US 9607445 W 19960522
  • US 47381795 A 19950607

Abstract (en)

[origin: WO9640122A1] A pharmaceutical composition for the treatment of leukemia in mammals is disclosed. The particular fungicide used is a benzimidazole derivative of formula (I), wherein X is hydrogen, halogen, alkyl of less than 7 carbon atoms or alkoxy of less than 7 carbon atoms; n is a positive integer of less than 4; Y is hydrogen, chlorine, nitro, methyl or ethyl; and R is hydrogen or an alkyl group having from 1 to 8 carbon atoms, and R2 is 4-thiazolyl or NHCOOR1 wherein R1 is aliphatic hydrocarbon of less than 7 carbon atoms or the pharmaceutically acceptable inorganic or acid addition salts thereof.

IPC 1-7

A61K 31/415

IPC 8 full level

C07D 417/04 (2006.01); A61K 31/415 (2006.01); A61K 31/4184 (2006.01); A61K 31/427 (2006.01); A61P 35/02 (2006.01)

CPC (source: EP KR)

A61K 31/415 (2013.01 - KR); A61K 31/4184 (2013.01 - EP); A61K 31/427 (2013.01 - EP); A61P 35/02 (2018.01 - EP); Y02A 50/30 (2018.01 - EP)

Citation (examination)

  • WO 9632107 A1 19961017 - PROCTER & GAMBLE [US]
  • LAPPRAS M, ET AL.: "ETUDE EXPERIMENTALE DES PROPTIETES ANTICANCEREUSES POTENTIELLES DU PARBENDAZOLE (SKF 29044)", BULLETIN DE LA SOCIETE DES SCIENCES VETERINAIRES ET DE MEDECINECOMPAREE DE LYON, DE LYON, LYON, vol. 77, 1 January 1975 (1975-01-01), pages 379 - 397, XP000915864, ISSN: 0301-1194
  • MARINOVICH M., GUIZZETTI M., GALLI C. L.: "MIXTURES OF BENOMYL, PIRIMIPHOS-METHYL, DIMETHOATE, DIAZINON AND AZINPHOS-METHYL AFFECT PROTEIN SYNTHESIS IN HL-60 CELLS DIFFERENTLY", TOXICOLOGY., LIMERICK, IR, vol. 94., no. 01/03., 1 January 1994 (1994-01-01), IR, pages 173 - 185., XP000579566, ISSN: 0300-483X, DOI: 10.1016/0300-483X(94)90036-1
  • See also references of WO 9640122A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9640122 A1 19961219; AR 003137 A1 19980708; AU 5802096 A 19961230; AU 717382 B2 20000323; BR 9608730 A 19990629; CA 2223435 A1 19961219; CN 1186433 A 19980701; CZ 391197 A3 19980513; EP 0831816 A1 19980401; HU P9802634 A2 19990329; HU P9802634 A3 19990528; IL 118424 A0 19960912; JP H11506732 A 19990615; KR 19990022617 A 19990325; NO 975660 D0 19971205; NO 975660 L 19980209; PL 324026 A1 19980511; SK 168697 A3 19981202; TR 199701536 T1 19980221; ZA 964373 B 19960902

DOCDB simple family (application)

US 9607445 W 19960522; AR 10304396 A 19960607; AU 5802096 A 19960522; BR 9608730 A 19960522; CA 2223435 A 19960522; CN 96194465 A 19960522; CZ 391197 A 19960522; EP 96914749 A 19960522; HU P9802634 A 19960522; IL 11842496 A 19960527; JP 50066797 A 19960522; KR 19970709098 A 19971206; NO 975660 A 19971205; PL 32402696 A 19960522; SK 168697 A 19960522; TR 9701536 T 19960522; ZA 964373 A 19960529