EP 0831920 A1 19980401 - NOVEL CATHEPSIN AND METHODS AND COMPOSITIONS FOR INHIBITION THEREOF
Title (en)
NOVEL CATHEPSIN AND METHODS AND COMPOSITIONS FOR INHIBITION THEREOF
Title (de)
NEUES CATHEPSIN SOWIE VERFAHREN UND ZUSAMMENSETZUNGEN ZUR INHIBIERUNG DESSELBEN
Title (fr)
NOUVELLE CATHEPSINE ET PROCEDES ET COMPOSITIONS D'INHIBITION DE CATHEPSINE
Publication
Application
Priority
- US 9606211 W 19960426
- US 46760795 A 19950606
- US 46936295 A 19950606
Abstract (en)
[origin: WO9639194A1] Methods for inhibiting the secretion of beta -amyloid peptide ( beta AP) from cells comprise administering to the cells certain compounds which inhibit the activity of an approximately 31 kD protease involved in beta AP secretion. The 31 kD protease has been designated Cathepsin Y. Screening methods for beta AP inhibitors rely on determining the activity of test compounds in the presence of Cathepsin Y and a suitable peptide substrate. This invention is also directed to a nucleic acid sequence that encodes Cathepsin Y and the expression and isolation of Cathepsin Y.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 31/165 (2006.01); A61K 31/27 (2006.01); A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 31/405 (2006.01); A61K 31/47 (2006.01); A61K 31/472 (2006.01); A61K 38/00 (2006.01); A61P 25/28 (2006.01); C07D 209/20 (2006.01); C07D 217/06 (2006.01); C07K 5/06 (2006.01); C07K 5/065 (2006.01); C07K 5/072 (2006.01); C12N 9/64 (2006.01); C12Q 1/68 (2006.01)
CPC (source: EP)
A61P 25/28 (2017.12); C07K 5/06034 (2013.01); C07K 5/06078 (2013.01); C07K 5/06095 (2013.01); C12N 9/6472 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9639194 A1 19961212; CA 2221684 A1 19961212; EP 0831920 A1 19980401; EP 0831920 A4 20030319; JP H11506923 A 19990622
DOCDB simple family (application)
US 9606211 W 19960426; CA 2221684 A 19960426; EP 96913917 A 19960426; JP 50050797 A 19960426