EP 0832059 A1 19980401 - METHOD FOR THE PREPARATION OF AN N-(2-BROMOALKYL)-AMIDE DERIVATIVE
Title (en)
METHOD FOR THE PREPARATION OF AN N-(2-BROMOALKYL)-AMIDE DERIVATIVE
Title (de)
VERFAHREN ZUR HERSTELLUNG VON N-(2-BROMOALKYL)-AMIDE-DERIVATE
Title (fr)
PROCEDE DE PREPARATION D'UN DERIVE N-(2-BROMOALKYL)-AMIDE
Publication
Application
Priority
- BE 9500528 A 19950614
- NL 9600237 W 19960613
Abstract (en)
[origin: WO9700237A1] The invention relates to a method for the preparation of an N-(2-bromoalkyl)-amido derivative according to formula (1), wherein an alkenically unsaturated compound (alkene) is brought into contact with a donor of a positive bromine ion and a nitrile in the presence of water or an acid, preferably sulphuric acid. The invention also relates to the use of an N-(2-bromoalkyl)-amido derivative thus obtained in the preparation of 1,2-aminoalcohols, beta -amido- alpha -hydroxycarboxylic acids, beta -amino acids, beta -amido acids, beta -aminonitriles, beta -amidonnitriles, beta -amido- alpha -hydroxynitriles, beta -aminoamides, beta -amidoamides or beta -amido- alpha -hydroxyamides, in particular a method for the preparation of a 1,2-aminoalcohol, an N-(2-bromoalkyl)-amido derivative first being subjected to a ring closure, preferably under acidic conditions, and optionally subsequently being subjected to a preferably acidic hydrolysis. Such 1,2-aminoalcohols can suitably be used in the preparation of known pharmaceuticals. A particularly attractive method for the preparation of a 1,2-aminoalcohol is obtained if the total route from the alkene is carried out without the products formed intermediately being isolated in between.
IPC 1-7
IPC 8 full level
A61K 31/135 (2006.01); A61P 31/12 (2006.01); C07C 213/00 (2006.01); C07C 215/46 (2006.01); C07C 231/06 (2006.01); C07C 233/13 (2006.01); C07C 233/14 (2006.01); C07C 233/47 (2006.01)
CPC (source: EP)
A61P 31/12 (2017.12); C07C 213/00 (2013.01); C07C 231/06 (2013.01); C07C 2602/08 (2017.04)
Citation (search report)
See references of WO 9700237A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB IE IT LI NL PT SE
DOCDB simple family (publication)
WO 9700237 A1 19970103; BE 1009427 A3 19970304; EP 0832059 A1 19980401; JP H11507665 A 19990706
DOCDB simple family (application)
NL 9600237 W 19960613; BE 9500528 A 19950614; EP 96917728 A 19960613; JP 50294597 A 19960613