EP 0832064 A1 19980401 - 5-AMINOALKYL-2-(2-ALKOXYPHENYL)-PYRROLE DERIVATIVES HAVING AFFINITY FOR DOPAMINE D3 RECEPTORS AND THEIR USE IN THE TREATMENT OF PSYCHOSES
Title (en)
5-AMINOALKYL-2-(2-ALKOXYPHENYL)-PYRROLE DERIVATIVES HAVING AFFINITY FOR DOPAMINE D3 RECEPTORS AND THEIR USE IN THE TREATMENT OF PSYCHOSES
Title (de)
5-AMINOALKYL-2-(2-ALKOXYPHENYL)-PYRRL DERIVATE MIT DOPAMINE D3 RECEPTOR-AFFINITAT UND IHR EINSATZ IN DER BEHANDLUNG VON PSYCHOSEN
Title (fr)
DERIVES DE 5-AMINOALKYLE-2-(2-ALKOXYPHENYL)-PYRROLE COMPORTANT UNE AFFINITE POUR DES RECEPTEURS DE DOPAMINE D3 ET LEUR UTILISATION POUR LE TRAITEMENT DES PSYCHOSES
Publication
Application
Priority
- EP 9602498 W 19960607
- GB 9512129 A 19950615
Abstract (en)
[origin: WO9700243A1] Compounds of Formula (I) wherein R<1> represents C1-4alkyl; R<3> represents an optionally substituted phenyl group or an optionally substituted 5- or 6-membered heterocyclic aromatic group; R<2>, R<4> and R<5> each independently represent hydrogen, halogen; C1-4alkyl; C1-4alkoxy; C1-4alkoxyC1-4alkyl; C1-4alkylsulphonyl; trifluoromethylsulphonyl; optionally substituted arylsulphonyl; optionally substituted heteroarylsulphonyl; optionally substituted aralkylsulphonyl; optionally substituted heteroaralkylsulphonyl; nitro; cyano; amino; mono- or di-C1-4alkylamino; trifluoromethyl; trifluoromethoxy; hydroxyl; hydroxyC1-4alkyl; C1-4alkylthio; C1-4alkanoyl C1-4alkoxycarbonyl; a sulphonate group of formula R<8>OSO2 wherein R<8> is an optionally substituted aryl or optionally substituted heteroaryl group; or a group -SO2NR<6>R<7> wherein R<6> and R<7> each independently represent hydrogen, C1-4alkyl or C1-4alkoxyC1-4alkyl, or R<6> represents hydrogen, C1-6alkyl, or C1-4alkoxyC1-4alkyl; and R<7> represents a group (R<a>)p-(Ar)-(CH2)j- wherein Ar represents phenyl, naphthyl, a 5- or 6-membered heterocyclic aryl group, or a 5- or 6- membered heterocyclic aryl group fused to a phenyl ring; j represents zero or an integer from 1-4; R<a> represents a substituent selected from halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, nitro, cyano, trifluoromethyl, trifluoromethoxy, hydroxy, hydroxyC1-4alkyl, C1-4alkanoyl, C1-4alkoxycarbonyl, amino, mono- or di-C1-4alkylamino, C1-4alkylthio, C1-4alkylsulphinyl, C1-4alkylsulphonyl and phenylC1-4alkoxy; and p represents zero or an integer from 1-4; or NR<6>R<7> forms a 3- to 8- membered fully saturated heterocyclic ring, a 5- to 8- membered partially saturated heterocyclic ring, a 5- to 8- membered fully saturated heterocyclic ring which contains in addition to the nitrogen atom an oxygen or sulphur atom; or a 5-7 membered heterocyclic ring which is fused to or substituted by a phenyl group, orsubstituted by a 5- or 6-membered heterocyclic aryl group, said phenyl or heteroaryl group being optionally substitued by a group (R<a>)p, wherein R<a> and p are as defined hereinabove; or R<1> and R<2> together form a C2-4alkyl chain, which chain may be optionally substituted by one or two C1-4alkyl groups, and R<3>, R<4> and R<5> are as hereinbefore defined; and Y represents a group selected from (a) - (e) and salts thereof, are dopamine D3 antagonists with potential for the treatment of schizophrenia.
IPC 1-7
IPC 8 full level
C07D 207/323 (2006.01); A61K 31/40 (2006.01); A61P 25/18 (2006.01); A61P 43/00 (2006.01); C07D 207/335 (2006.01); C07D 207/32 (2006.01)
CPC (source: EP)
A61P 25/18 (2017.12); A61P 43/00 (2017.12); C07D 207/335 (2013.01)
Citation (search report)
See references of WO 9700243A1
Designated contracting state (EPC)
BE CH DE ES FR GB IT LI NL
DOCDB simple family (publication)
WO 9700243 A1 19970103; EP 0832064 A1 19980401; GB 9512129 D0 19950816; JP H11507657 A 19990706
DOCDB simple family (application)
EP 9602498 W 19960607; EP 96920811 A 19960607; GB 9512129 A 19950615; JP 50260897 A 19960607