EP 0832219 A2 19980401 - CHIMERIC LEPTIN FUSED TO IMMUNOGLOBULIN DOMAIN AND USE
Title (en)
CHIMERIC LEPTIN FUSED TO IMMUNOGLOBULIN DOMAIN AND USE
Title (de)
CHIMÄRES, MIT EINER IMMUNGLOBULINDOMÄNE FUSIONIERTES LEPTID UND SEINE VERWENDUNG
Title (fr)
LEPTINE CHIMIRASEE PAR FUSION AVEC UN DOMAINE D'IMMUNOGLOBULINE ET UTILISATION CORRESPONDANTE
Publication
Application
Priority
- GB 9601388 W 19960611
- GB 9511935 A 19950613
Abstract (en)
[origin: WO9700319A2] Chimeric leptin which are proteins comprising leptin or a mutant or a variant thereof fused to a human immunogobulin domain. One favoured immunoglobulin domain is the human immunoglobulin Fc domain. The chimeric derivatives of leptin have, despite their large molecular size, good pharmacological activity combined with prolonged clearance rates. These derivatives of leptin are therefore indicated to be particularly useful for the treatment or prophylaxis of obesity or diseases and conditions associated with obesity such as atherosclerosis, hypertension and type II diabetes.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61P 3/04 (2006.01); C07K 14/47 (2006.01); C07K 14/575 (2006.01); C07K 16/00 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01)
CPC (source: EP)
A61P 3/04 (2017.12); C07K 14/5759 (2013.01); C07K 19/00 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 9700319A2
Designated contracting state (EPC)
BE CH DE DK ES FR GB IT LI NL
DOCDB simple family (publication)
WO 9700319 A2 19970103; WO 9700319 A3 19970410; AU 6011096 A 19970115; CA 2224646 A1 19970103; EP 0832219 A2 19980401; GB 9511935 D0 19950809; JP H11507547 A 19990706
DOCDB simple family (application)
GB 9601388 W 19960611; AU 6011096 A 19960611; CA 2224646 A 19960611; EP 96917584 A 19960611; GB 9511935 A 19950613; JP 50278497 A 19960611