EP 0832223 A1 19980401 - C5a RECEPTOR ANTAGONISTS HAVING SUBSTANTIALLY NO AGONIST ACTIVITY AND METHODS FOR PREPARATION
Title (en)
C5a RECEPTOR ANTAGONISTS HAVING SUBSTANTIALLY NO AGONIST ACTIVITY AND METHODS FOR PREPARATION
Title (de)
ANTAGONISTEN VON C 5A-REZEPTOREN OHNE AGONISTISCHE WIRKUNG UND VERFAHREN ZU DEREN HERSTELLUNG
Title (fr)
ANTAGONISTES DES RECEPTEURS DE C5a NE PRESENTANT SENSIBLEMENT AUCUNE ACTIVITE AGONISTE ET LEURS PROCEDES DE PREPARATION
Publication
Application
Priority
- EP 9602422 W 19960604
- US 46322495 A 19950605
- US 46337795 A 19950605
- US 46264895 A 19950605
Abstract (en)
[origin: WO9639503A1] Disclosed are polypeptide analogues or derivatives of human C5a which are C5a receptor antagonists that exhibit substantially no analphylatoxin or agonist activity, and derivatives of the analogues, and dimeric forms of the analogues or derivatives. DNA molecules encoding the polypeptides and methods of making the analogues are also provided. Pharmaceutical formulations containing a C5a analogue or derivative, are used therapeutically in the treatment of C5a-mediated diseases and inflammatory conditions in mammals, and prophylactically to prevent or reduce inflammation caused by an event which causes inflammation or aggravates an existing inflammatory condition, respectively. Further disclosed are antibodies specific to the C5a analogues, derivatives thereof, and dimers of the analogues and derivatives which exhibit substantially no cross-reactivity with human C5a. The antibodies are used to detect or quantify circulating C5a analogue or derivative, as well as to modify, e.g., neutralize, the activity of the C5a receptor antagonist in vivo.
IPC 1-7
C12N 15/12; C07K 14/47; C07K 16/18; A61K 38/17; G01N 33/68; C12N 15/62
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); C07K 1/107 (2006.01); C07K 7/06 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/02 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01)
CPC (source: EP)
A61P 29/00 (2017.12); A61P 37/00 (2017.12); C07K 14/472 (2013.01); C07K 16/18 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 9639503A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9639503 A1 19961212; AU 6125096 A 19961224; EP 0832223 A1 19980401; JP H11507215 A 19990629
DOCDB simple family (application)
EP 9602422 W 19960604; AU 6125096 A 19960604; EP 96918669 A 19960604; JP 50013897 A 19960604