Global Patent Index - EP 0833641 A4

EP 0833641 A4 2000-04-05 - TREATMENT AND PREVENTION OF PROSTATIC DISEASE

Title (en)

TREATMENT AND PREVENTION OF PROSTATIC DISEASE

Title (de)

BEHANDLUNG UND VORBEUGUNG VON ERKRANKUNGEN DER PROSTATA

Title (fr)

TRAITEMENT ET PREVENTION DE MALADIES PROSTATIQUES

Publication

EP 0833641 A4 (EN)

Application

EP 96917173 A

Priority

  • US 9608873 W
  • US 48463395 A

Abstract (en)

[origin: WO9640150A1] The present invention is related to a method for treating and preventing benign prostatic hyperplasia (BPH) and prostatic carcinoma by administering a therapeutically effective amount of a compound which binds to SHBG and antagonizes the SHBG-mediated effects of both estradiol and 5 alpha -androstan-3 alpha ,17 beta diol by preventing the binding of estradiol and 5 alpha -androstan-3 alpha ,17 beta diol. The present invention further relates to the compounds which bind SHBG and prevent the binding of estradiol and 5 alpha -androstan-3 alpha ,17 beta diol as well as to a method of finding compounds which bind to SHBG and prevent the binding of estradiol

IPC 1-7 (main, further and additional classification)

A61K 31/56

IPC 8 full level (invention and additional information)

A61K 45/00 (2006.01); A61K 31/565 (2006.01); A61K 31/58 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01)

CPC (invention and additional information)

A61K 31/568 (2013.01); A61K 31/565 (2013.01); A61K 31/58 (2013.01)

Combination set (CPC)

  1. A61K 31/565 + A61K 2300/00
  2. A61K 31/58 + A61K 2300/00

Citation (search report)

  • [X] WO 9100095 A1 19910110 - COHEN MICHAEL [NL]
  • [X] WO 9504535 A1 19950216 - CHILDRENS MEDICAL CENTER [US]
  • [Y] WO 9418936 A1 19940901 - RINGLER STEVEN L [US], et al
  • [Y] VERHELST, J. ET AL: "Endocrine profiles during administration of the new non-steroidal anti-androgen Casodex in prostate cancer", CLIN. ENDOCRINOL, vol. 41, no. 4, 1994, Oxford, pages 525 - 30, XP002128735
  • [A] PLYMATE S.R. ET AL.: "Effects of sex hormone binding globulin (SHBG) on human prostatic carcinoma", J. STEROID BIOCHEM MOL BIOL, vol. 40, no. 4-6, 1991, USA, pages 833 - 9, XP002128736
  • [A] NAKHLA, A. M. ET AL.: "Sex hormone-binding globulin (SHBG) and estradiol, but not dihydrotestosterone, act together to increase intracellular cAMP in human benign prostatic hypertrophy.", JOURNAL OF UROLOGY, vol. 151, no. 5, 1994, pages 382A, XP002128737
  • [A] SCHMIDT, K.: "Effect of radix urticae extract and its several secondary extracts on blood SHBG in benign prostate.", FORTSCHRITTE DER MEDIZIN, vol. 101, no. 15, 1983, pages 713 - 6, XP002128738
  • See also references of WO 9640150A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9640150 A1 19961219; AU 5984196 A 19961230; CA 2222625 A1 19961219; EP 0833641 A1 19980408; EP 0833641 A4 20000405; JP H11507050 A 19990622

INPADOC legal status


2001-03-07 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20000426

2000-04-05 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20000221

2000-04-05 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

1998-04-08 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19980107

1998-04-08 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE